889100-68-9Relevant academic research and scientific papers
pKa values of aqua ligands of platinum(II) anticancer complexes: [1H, 15N] and 195Pt NMR studies of cis- and trans-[PtCl2 (NH3)(cyclohexylamine)]
Barton, Sarah J.,Barnham, Kevin J.,Habtemariam, Abraha,Sue, Rodney E.,Sadler, Peter J.
, p. 8 - 13 (2008/10/08)
Syntheses and NMR studies are reported of two 15N-labelled Pt(II) complexes of anticancer interest: cis-[PtCl2(15NH3)(c-C6H 1115NH2)], a metabolite of the orally-active Pt(IV) complex cis,trans,cis-[PtCl2(acetate)2(c-C6H 11NH2)(NH3)], and trans-[PtCl2(15NH3)(c-C6H 1115NH2)], a reduction product of the active Pt(IV) complex trans,trans,trans-[PtCl2(OH)2(c-C6H 11NH2)]. For cis-[PtCl2(15NH3)(c-C6H 1115NH2)], hydrolysis was faster for the chloride ligand trans to cyclohexylamine, and the pKa values determined by [1H, 15N] NMR spectroscopy for the two cis monoaqua isomers were the same (6.73). The trans monoaqua complex was a stronger acid with pKa of 5.4 (determined by 195Pt NMR). For the cis diaqua complex, pKa values of 5.68 and 7.68 were determined.
