88911-34-6Relevant academic research and scientific papers
AN IMPROVED ROUTE TO (+)-9(O)-METHANO-Δ6(9Α)-PROSTAGLANDIN-I1 (ISOCARBACYCLIN)
Torisawa, Yasuhiro,Okabe, Hiromitsu,Shibasaki, Masakatsu,Ikegami, Shiro
, p. 1069 - 1072 (2007/10/02)
An improved synthesis of the title compound and a synthesis of its derivatives are described, in which the regiospecific transformation of the diene into diol was effectiely achived by using thexylborane.
PRACTICAL SYNTHESIS OF (+)-9(O)-METHANO-Δ6(9α)-PGI1. THE HIGHLY POTENT CARBON ANALOG OF PROSTACYCLIN
Sodeoka, Mikiko,Shibasaki, Masakatsu
, p. 579 - 582 (2007/10/02)
A practical synthesis of (+)-9(O)-methano-Δ6(9α)-PGI1, potentially a useful therapeutic agent, has been accomplished by utilizing the intramolecular aldol condensation as key step followed by the Wittig reaction and the regioselective hydrogenation.
THE INTRAMOLECULAR THERMAL ENE REACTION ROUTE TO (+)-9(O)-METHANO-Δ6(9α)-PGI1
Ogawa, Yuji,Shibasaki, Masakatsu
, p. 1067 - 1070 (2007/10/02)
(+)-9(O)-Methano-Δ6(9α)-PGI1, a more potent carbon analog than carbacyclin, has been synthesized from the Corey lactone by utilizing the intramolecular thermal ene reaction as a key step.
REGIOCONTROLLED CONVERSION OF α,α-UNSATURATED KETONES TO OLEFINS VIA ALLYLSILANES: SYNTHESIS OF dl-9(O)-METHANO-Δ6(9α)-PGI1
Shibasaki, Masakatsu,Fukasawa, Hidemi,Ikegami, Shiro
, p. 3497 - 3500 (2007/10/02)
A synthesis of dl-9(O)-methano-Δ6(9α)-PGI1 (1), a more potent prostacyclin analog than carbacyclin, has been accomplished utilizing regiocontrolled transformation of the enone to the olefin via the allylsilane as a key step.
Synthesis of 9(0)-methano-Δ6(9α)-PGI1: The highly potent carbon analog of prostacyclin
Shibasaki,Torisawa,Ikegami
, p. 3493 - 3496 (2007/10/02)
A new prostacyclin analog, 9(o)-methano-Δ6(9α)-PGI1, was synthesized by utilizing intramolecular pinacolic coupling reaction as the key step and was shown to be more potent than carbacyclin in inhibition of platelet aggregation.
