889127-15-5Relevant academic research and scientific papers
Iridium-catalyzed enantioselective allylic substitutions with aliphatic nitro compounds as prenucleophiles
Dahnz, Axel,Helmchen, Günter
, p. 697 - 700 (2006)
Enantioselective Ir-catalyzed allylic alkylations with nitroalkanes and ethyl nitroacetate as nucleophiles are reported. Up to 99% ee was achieved using catalysts prepared by in situ activation of mixtures of phosphorus amidites and [Ir(COD)Cl]2. The method was applied to a synthesis of the antidepressant (1S,2R)-trans-2-phenylcyclopentanamine. Georg Thieme Verlag Stuttgart.
