889129-46-8Relevant academic research and scientific papers
Parallel synthesis and spectroscopic analysis of a collection of heterocycles based on the diazabenz[e]aceanthrylene core structure
Jones, Alan M.,Lebl, Tomas,Patterson, Stephen,van Mourik, Tanja,Früchtl, Herbert A.,Philp, Douglas,Slawin, Alexandra M.Z.,Westwood, Nicholas J.
supporting information; experimental part, p. 563 - 578 (2009/04/06)
A practical strategy for the synthesis of diazabenz[e]aceanthrylene-based heterocycles is reported. The key step in this approach is a microwave-assisted condensation and cyclisation reaction between an anthranilic acid derivative and a 2′-carbomethoxy substituted N-aryl lactam. The scope of the reaction has been explored as a function of both the nature and position of substituents in both components and variations in lactam ring size. Interesting structural and spectroscopic variations observed across the compound collection are described and explored using NMR, X-ray crystallography and computational techniques.
Synthesis of a new family of N-aryl lactams active on chemesthesis and taste
Bassoli, Angela,Borgonovo, Gigliola,Busnelli, Gilberto,Morini, Gabriella
, p. 1656 - 1663 (2007/10/03)
A new class of synthetic compounds with chemesthetic activity has been identified. They have been designed ex-novo by structural similarity with known cooling compounds such as menthol, icilin and cyclic ketoenamines. 19 new derivatives have been obtained
