889131-28-6

Basic information

• Product Name: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride
• Synonyms: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride;1,3,4-Oxadiazole-2-carbonyl chloride, 5-methyl-
• CAS NO: 889131-28-6
• Molecular Formula: C₄H₃ClN₂O₂
• Molecular Weight: 146.53182
• Mol File: 889131-28-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 250.0±23.0 °C(Predicted)
• Appearance: /
• Density: 1.445±0.06 g/cm3(Predicted)
• PKA: -5.44±0.10(Predicted)
• CAS DataBase Reference: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride(889131-28-6)
• EPA Substance Registry System: 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride(889131-28-6)

Safety Data

• Hazardous Substances Data: 889131-28-6(Hazardous Substances Data)

Usage

Uses

5-Methyl-1,3,4-oxadiazole-2-carbonyl Chloride is a reagent in the preparation of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.

Upstream product

• 888504-28-7 5-methyl-1,3,4-oxadiazole-2-carboxylic acid potassium salt 

Downstream Products

• 518048-05-0 raltegravir 
• 1172131-66-6 C₂₅H₂₉FN₆O₆ 
• 1328839-28-6 C₂₄H₂₃FN₈O₇ 
• 1193687-87-4 raltegravir 
• 1391918-18-5 C₃₄H₃₆F₂N₈O₈ 
• 1370588-47-8 methyl 5-(benzoyloxy)-6-methoxy-2-(2-(5-methyl-1,3,4-oxadiazole-2-carboxamido)propan-2-yl)pyrimidine-4-carboxylate 

Relevant articles and documents

Seeking for Selectivity and Efficiency: New Approaches in the Synthesis of Raltegravir

The present work describes the development of an improved synthesis of active pharmaceutical ingredient raltegravir. The isolation of a new process intermediate and the newly developed conditions solve the issue of selectivity typical of this production process, with no need for the use of protecting groups, making the present route more efficient and sustainable than what was reported before. Efficiency comparisons with the previous processes confirm the result here obtained.

Preparation method of pyrimidinone amide type compound

The invention discloses a pyrimidinone amide type compound and a preparation method thereof. A pyrimidinone compound is taken as a starting material and is subjected to four-step chemical conversion to obtain TN-A005 and an analogue thereof, and an intermediate can be prepared from methyl tetrazole. A one-pot method is used for feeding in the whole preparation process, post-treatment purificationof each step is recrystallization or dispersion washing, the use of means such as silica gel column chromatography is avoided, the preparation technology is greatly simplified, the preparation efficiency is improved, and the total yield can reach 50%. The method is simple and convenient in preparation steps and can improve the preparation efficiency.

3. 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)

The invention discloses 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application. In particular, the invention relates to the formula (I) structure of 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivatives, its stereoisomers or its pharmaceutically acceptable salt, formula (I) in the definition of each substituent is as defined in the specification. These structure of novel compound with heat shock protein HSP90 inhibitory activity, can be used for treating cancer, neurodegenerative diseases, inflammatory diseases, autoimmune diseases, ischemic brain injury and the like, it has broad application prospects. (by machine translation)