88929-24-2Relevant academic research and scientific papers
Roof shape amines: Synthesis and application as NMR chiral solvating agents for discrimination of α-functionalized acids We wish to dedicate this paper to Professor Sukh Dev on the occasion of his 90th birthday
Jain, Nilesh,Mandal, Monali B.,Bedekar, Ashutosh V.
, p. 4343 - 4354 (2014)
A series of new chiral roof shape amines have been prepared from anthracene involving simple chemical steps and enzymatic resolution of isomers. The amines were screened as chiral solvating agents for the discrimination of enantiomers of several α-functionalized acids by the 1H NMR analysis. The system can also be used to accurately measure enantiomeric excess of mandelic acid by 1H NMR analysis. The roof shape CSAs were capable of detecting the shift in the signals for the standard four nuclei of 1H, 13C, 19F and 31P of various optically active acids.
Lipase catalyzed resolution of trans-11,12-bis(hydroxymethyl)-9,10-dihydro- 9,10-ethanoanthracene: Facile access to both enantiomers and the synthesis of their amino derivatives
Jain, Nilesh,Bedekar, Ashutosh V.
, p. 1176 - 1179 (2011/10/17)
The lipase mediated resolution of roof shaped trans-11,12- bis(hydroxymethyl)-9,10-dihydro-9,10-ethanoanthracene using vinyl acetate as an acetylating reagent is achieved. This method gives easy access to both enantiomers of the molecule in very high enantiomeric purity. The chiral diol is converted to diamino and aminoalcohol derivatives by simple chemical transformations.
