88949-92-2Relevant articles and documents
Synthesis of novel scaffolds based on thiazole or triazolothiadiazine linked to benzofuran or benzo[d]thiazole moieties as new hybrid molecules
Salem, Mostafa E.,Darweesh, Ahmed F.,Elwahy, Ahmed H. M.
, p. 256 - 270 (2020)
A synthesis of novel hybrid molecules containing thiazole or bis(thiazoles) each bearing benzofuran and/or benzo[d]thiazole moieties by the reaction of the appropriate thioamide derivatives with the corresponding bis-bromoacetyl derivatives is reported. M
Facile synthesis and characterization of novel benzo-fused macrocyclic dicarbonitriles and pyrazolo-fused macrocycles containing thiazole subunits
Ahmed, Ahmed A. M.,Elwahy, Ahmed H. M.,Mekky, Ahmed E. M.,Sanad, Sherif M. H.
, (2020)
Novel bis[2-(thiazol-2-yl)acetonitriles], linked to aliphatic cores via ethers, were prepared by the reaction of the appropriate bis(2-bromoethan-1-one) with 2-cyanothioacetamide in dioxane at reflux. Bis[2-(thiazol-2-yl)acetonitriles] were taken as key intermediates for the preparation of a new class of macrocyclic dicarbonitriles bearing two thiazole units and containing two O2-donor sets and fused with two benzene units. The target macrocyclic dicarbonitriles were prepared by the cyclocondensation of bis[2-(thiazol-2-yl)acetonitriles] with the appropriate bis(aldehydes) in N,N-dimethylformamide in the presence of piperidine at reflux. Moreover, a new class of pyrazolo-fused macrocycles containing thiazole subunits were prepared by the reaction of macrocyclic dicarbonitriles with hydrazine hydrate in ethanol at reflux. The structures of the novel macrocycles bearing thiazole subunits were elucidated by considering their elemental analyses as well as their IR, mass, 1H NMR and 13C NMR spectral data.
Microwave assisted synthesis of novel 1,ω-bis(quinoxalin-2-yl)phenoxy)alkanes or arenes
Abd El-Fatah, Nesma A.,Darweesh, Ahmed F.,Salem, Mostafa E.,Abdelhamid, Ismail A.,Elwahy, Ahmed H.M.
, p. 252 - 266 (2020/02/13)
A synthesis of a novel series of bis(quinoxaline) derivatives by the reaction of o-phenylenediamine with the appropriate bis(α-bromoketones) was reported. The reactions were performed under thermal as well as under microwave irradiation conditions. The re
Synthesis of Novel Bis(thiazolylchromen-2-one) Derivatives Linked to Alkyl Spacer via Phenoxy Group
Hosny, Mohamed,Salem, Mostafa E.,Darweesh, Ahmed F.,Elwahy, Ahmed H. M.
, p. 2342 - 2348 (2018/09/12)
A novel series of bis(thiazolylchromen-2-one) derivatives 8 were prepared in good yields by the reaction of the appropriate bis(α-bromoketones) 7 with 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene) hydrazinecarbothioamide (6) in refluxing EtOH in the presence of
Bis(α-bromo ketones): Versatile precursors for novel Bis(s-triazolo[3,4-b][1,3,4]thiadiazines) and Bis(as-triazino[3,4-b][1,3,4] thiadiazines)
Shaaban, Mohamed R.,Elwahy, Ahmed H. M.
, p. 640 - 645 (2012/09/07)
A synthesis of bis(α-bromo ketones) 5a-c and 6b,c was accomplished by the reaction of bis(acetophenones) 3a-c and 4b,c with N-bromosuccinimide in the presence of p-toluenesulfonic acid (p-TsOH). Treatment of 5a-c and 6b,c with each of 4-amino-3-mercapto-1
