88950-08-7

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 99-93-4 4-Hydroxyacetophenone 
• 97921-46-5 1,1'-((butane-1,3-diylbis(oxy))bis(4,1-phenylene))diethanone 

Downstream Products

• 1390658-63-5 1,4-bis{4-(3-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-6-yl)-phenoxy}butane 
• 1390658-52-2 1,4-bis{4-(3-phenyl-[1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4(8H)-on-7-yl)phenoxy}butane 
• 1390658-61-3 1,4-bis{4-(3-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-6-yl)phenoxy}butane 

Relevant academic research and scientific papers

Sequential one-pot multicomponent synthesis of bis-aminothiazols and evaluation of their antibacterial and antioxidant activities

A series of novel bis-thiazoles were synthesized through a one-pot semi-five-component reaction of the prepared α-bisbromo ketones, aldehydes, and thiosemicarbazide in the presence of p-TsOH under reflux condition. Products were obtained in reasonable yie

Synthesis of novel scaffolds based on thiazole or triazolothiadiazine linked to benzofuran or benzo[d]thiazole moieties as new hybrid molecules

A synthesis of novel hybrid molecules containing thiazole or bis(thiazoles) each bearing benzofuran and/or benzo[d]thiazole moieties by the reaction of the appropriate thioamide derivatives with the corresponding bis-bromoacetyl derivatives is reported. M

Microwave assisted synthesis of novel 1,ω-bis(quinoxalin-2-yl)phenoxy)alkanes or arenes

A synthesis of a novel series of bis(quinoxaline) derivatives by the reaction of o-phenylenediamine with the appropriate bis(α-bromoketones) was reported. The reactions were performed under thermal as well as under microwave irradiation conditions. The re

Ultrasound and water-mediated synthesis of bis-thiazoles catalyzed by Fe(SD)3 as Lewis acid-surfactant-combined catalyst

Preparation of bis-aminothiazoles under different conditions including synthesis in EtOH under ultrasound irradiation and also in water in the presence of Fe(SD)3 as Lewis acid-surfactant-combined catalyst (LASC) under ultrasound irradiation has been studied. The results were compared with the traditional reflux method. Also, the results confirmed the efficiency of the synthesis in water and under ultrasound irradiation technique. Moreover, the antibacterial activity of products was investigated using the well-diffusion method against bacterial strains including Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis. All of the products showed good antibacterial activity against M. luteus and E. coli. Most of the products showed antibacterial activity higher than erythromycin against M. luteus, E. coli, and B. subtilis.

Synthesis of Novel Bis(thiazolylchromen-2-one) Derivatives Linked to Alkyl Spacer via Phenoxy Group

A novel series of bis(thiazolylchromen-2-one) derivatives 8 were prepared in good yields by the reaction of the appropriate bis(α-bromoketones) 7 with 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene) hydrazinecarbothioamide (6) in refluxing EtOH in the presence of

Facile regioselective synthesis of novel bis-thiazole derivatives and their antimicrobial activity

The design and synthesis of several new bis-thiazoles 4a-h serving as bis-drugs in comparison with mono-heterocyclic analogs are described. These bis-drugs present superior medicinal and pharmacological activities against both gram-negative (Pseudomonas a

Bis(α-bromo ketones): Versatile precursors for novel Bis(s-triazolo[3,4-b][1,3,4]thiadiazines) and Bis(as-triazino[3,4-b][1,3,4] thiadiazines)

A synthesis of bis(α-bromo ketones) 5a-c and 6b,c was accomplished by the reaction of bis(acetophenones) 3a-c and 4b,c with N-bromosuccinimide in the presence of p-toluenesulfonic acid (p-TsOH). Treatment of 5a-c and 6b,c with each of 4-amino-3-mercapto-1