88962-35-0

Usage

Uses

Used in Biochemical Research:
L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-seryl]-, 2-chloroethyl ester is used as a reagent in biochemical research for its ability to facilitate the synthesis of peptides and proteins. Its unique structure allows for the efficient incorporation of leucine into peptide chains, making it a valuable tool in the study of protein structure and function.
Used in Solid-Phase Peptide Synthesis:
In the pharmaceutical industry, L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-seryl]-, 2-chloroethyl ester is used as a key component in solid-phase peptide synthesis. This technique allows for the stepwise assembly of peptide chains on an insoluble resin support, enabling the production of large quantities of peptides with high purity and yield. The use of L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-seryl]-, 2-chloroethyl ester as a protecting group for serine residues ensures the selective deprotection and coupling of amino acids during the synthesis process.
Used in Peptide Drug Development:
L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-seryl]-, 2-chloroethyl ester is also utilized in the development of peptide-based drugs. Peptides have emerged as promising therapeutic agents due to their high specificity and potency. The use of L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-seryl]-, 2-chloroethyl ester in peptide synthesis allows for the creation of novel peptide drugs with potential applications in various therapeutic areas, such as oncology, immunology, and endocrinology.

Upstream product

• 61-90-5 L-leucine 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 20790-82-3 L-Leucine 2-chloroethyl ester hydrochloride 

Downstream Products

• 88962-61-2 (S)-2-[(S)-2-Benzyloxycarbonylamino-3-((3aR,5R,6R,7S,7aR)-6,7-diacetoxy-5-acetoxymethyl-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-2-yloxy)-propionylamino]-4-methyl-pentanoic acid 2-chloro-ethyl ester 
• 88962-58-7 N-Benzyloxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-L-seryl-L-leucin-2-chlorethylester 
• 33019-34-0 2-[(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)oxy]benzoic acid 

Relevant academic research and scientific papers

Glycopeptide Synthesis: Selective C-terminal Deblocking and Peptide Chain Elongation of Glucosylserine Derivatives

Benzyloxycarbonyl-(Z-)serine 2-bromoethyl ester (3b) reacts with 2,3,4,6-tetra-O-benzoyl-α-D-glucopyranosyl bromide (14) to give the glucosylserine ester 15.After conversion into the corresponding 2-iodoethyl ester 23 the carboxylic group is deblocked selectively by reductive elimination using zinc.In this procedure the Z and the carbohydrate protective functions as well as the sensitive O-glycoside bond remain unaffected.The glycosylserine 24 is condensed with amino acid 2-bromoethyl esters 2 to form protected glycodipeptide 2-bromoethyl esters 18 which are extended to give glycotripeptide esters 25 after selective carboxyl deblocking.Whereas protected serine dipeptides 5 are glycosylated with 14 to form the conjugates 18, the glycosylation of the serine tripeptides 10 was not successful.