88962-96-3Relevant academic research and scientific papers
TfOH-Catalyzed Phosphinylation of 2,3-Allenols into ?-Ketophosphine Oxides
Zhao, Runmin,Huang, Xianhua,Wang, Minning,Hu, Shanshan,Gao, Yuxing,Xu, Pengxiang,Zhao, Yufen
, p. 8185 - 8195 (2020/09/21)
The first facile and efficient acid-catalyzed direct coupling of a wide range of unprotected 2,3-allenols with arylphosphine oxides was developed, offering a general, one-step approach for the synthesis of structurally diverse ?-ketophosphine oxides accompanied by concurrent C-P/Ca?O bond formation with remarkable functional group tolerance and complete atom-economy under metal- A nd additive-free conditions. Mechanistic studies showed that this transformation involved a rearrangement and a phospha-Michael reaction.
