88975-08-0Relevant academic research and scientific papers
Method for preparing flurbiprofen impurity M
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Paragraph 0039; 0040, (2018/09/14)
The invention discloses a method for preparing a flurbiprofen impurity M. The method adopts 3,4-difluoronitrobenzene as an initial raw material to have substitution reaction with diethyl methylmalonate, and the flurbiprofen impurity M with high purity is
2-FLUOROPHENYL PROPIONIC ACID DERIVATIVES
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Paragraph 0045; 0094, (2014/11/13)
Provided are novel 2-fluorophenyl propionic acid derivatives which have excellent anti-inflammatory/analgesic effects while avoiding side effects such as gastrointestinal disorders, namely 2-fluorophenyl propionic acid derivatives represented by the formula (I) below or pharmaceutically acceptable salts thereof, [wherein, R1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group, X represents —CH2—, —NH—, —O—, or —S—, and Y specifically represents group (II) (wherein, Z1 represents —CO—, —CH(OH)—, or —CH2—, and n represents an integer of 1 or 2.)]
Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2- oxocyclopentyl)methyl]phenyl}propanoic acid: Nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity
Yamakawa, Naoki,Suemasu, Shintaro,Okamoto, Yoshinari,Tanaka, Ken-Ichiro,Ishihara, Tomoaki,Asano, Teita,Miyata, Keishi,Otsuka, Masami,Mizushima, Tohru
supporting information; experimental part, p. 5143 - 5150 (2012/09/07)
We previously reported that 2-fluoroloxoprofen has lower gastric ulcerogenic activity than loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID) without selectivity for COX-2. We synthesized derivatives of 2-fluoroloxoprofen and studied their properti
