88975-43-3Relevant academic research and scientific papers
SYNTHESIS AND STRUCTURE OF DERIVATIVES OF 7-OXO-4,5,6,7-TETRAHYDROBENZOTHIOPHENE AND 7-HYDROXYBENZOTHIOPHENE
Kharizomenova, I. A.,Kapustina, M. V.,Grinev, A. N.,Sheinker, Yu. N.,Alekseeva, L. M.,Kuleshova, E. F.
, p. 1339 - 1342 (1984)
The oxidation of 2-acylamino-3-ethoxycarbonyl-4,5,6,7-tetrahydrobenzothiophenes gave the corresponding 7-oxotetrahydrobenzothiophenes and some of the transformations of these compounds were studied.These compounds were used for the synthesis of 3-et
Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process for Making Them, and Use Thereof for Treating Pain and Other Conditions
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Page/Page column 41; 50; 53, (2009/07/03)
Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting pain and various other disorders or conditions.
FURAN OR THIOPHENE DERIVATIVE AND MEDICINAL USE THEREOF
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Page/Page column 102, (2008/06/13)
The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or -S(O)n- (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, -S(O)m-, -C(=O)-N(R3)- or -N(R3)-C(=O)- (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.
BENZOPYRAN AND RELATED LTB4 ANTAGONISTS
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, (2008/06/13)
The invention relates to benzopyran leukotriene B 4 (LTB. sub.4) antagonists and pharmaceutical compositions containing the compounds. The compounds inhibit the action of LTB 4 and are therefore useful in the treatment of LTB 4 induced illnesses such as inflammatory disorders.
