88976-53-8

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 937-52-0 (R)-1-methyl-3-phenylpropylamine 
• 81580-36-1 (R)-2-hydroxy-5-<acetyl>benzamide 
• 75659-07-3 (R,R)-labetalol 
• 83167-32-2 (S,R)-labetalol 
• 4187-36-4 ((R)-1-Methyl-3-phenyl-propyl)-[1-phenyl-meth-(E)-ylidene]-amine 
• 75659-06-2 (+)-(R)-α-methyl-N-(phenylmethyl)benzenepropanamine 

Relevant academic research and scientific papers

First efficient two-step/one-pot zirconium (IV)isopropoxide-mediated reductive amination of carbonyl compounds

An efficient method for the synthesis of various primary and secondary amines through a zirconium(IV) isopropoxide-mediated reductive amination reaction of aldehydes and ketones is reported. A series of different aldehydes, ketones and amines were used leading to the expected amino products in moderate to excellent yields. The mechanistic rationale of this reaction has been postulated through the formation of a transient imine species and a diastereoselective version using (R)-phenylethylamine as chiral inducer led to the expected products in moderate to excellent yields and with diastereoselectivities up to 100%.

METHODS FOR TREATING DISEASES ASSOCIATED WITH THE MODULATION OF SERCA

Provided herein are compounds, compositions, and methods for treating or ameliorating diseases associated with the modulation of SERCA.

SYNTHESIS OF AMINE STEREOISOMERS

The invention relates to methods for producing secondary and tertiary amine diastereomers and corresponding enantiopure or enantioenriched primary or secondary chiral amine products.

Evolution of titanium(IV) alkoxides and Raney Nickel for asymmetric reductive amination of prochiral aliphatic ketones

(Chemical Equation Presented) A new method for the one-pot asymmetric reductive amination of prochiral aliphatic ketones has been developed. The previously unexplored reagent combination of Ti(OiPr) 4/Raney Ni/H2 in the pr

Asymmetric reduction of enantiopure imines with zinc borohydride: Stereoselective synthesis of chiral amines

The first application of zinc borohydride in the reduction of enantiopure imines for the stereoselective preparation of both the enantiomers of secondary amines is described. A possible explanation of the stereoselectivity and of the reaction mechanism is