889884-60-0

Basic information

• Product Name: 7-Amino-5-chloro-2(3H)-benzoxazolone
• Synonyms: 7-Amino-5-chloro-2(3H)-benzoxazolone;2(3H)-Benzoxazolone,7-amino-5-chloro-
• CAS NO: 889884-60-0
• Molecular Formula: C₇H₅ClN₂O₂
• Molecular Weight: 184.00
• Product Categories: Chemical Amines;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 889884-60-0.mol

Chemical Properties

• Melting Point: >220?C (dec.)
• Appearance: /
• Density: 1.586 g/cm³
• Refractive Index: 1.669
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 7-Amino-5-chloro-2(3H)-benzoxazolone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Amino-5-chloro-2(3H)-benzoxazolone(889884-60-0)
• EPA Substance Registry System: 7-Amino-5-chloro-2(3H)-benzoxazolone(889884-60-0)

Safety Data

• Hazardous Substances Data: 889884-60-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Amino-5-chloro-2(3H)-benzoxazolone is used as a synthetic intermediate for the production of Bifeprunox, an antipsychotic compound. Bifeprunox is a novel atypical antipsychotic drug that targets both dopamine D2 and serotonin 5-HT1A receptors, offering potential therapeutic benefits for the treatment of schizophrenia and other related disorders. The unique structure of 7-Amino-5-chloro-2(3H)-benzoxazolone plays a crucial role in the synthesis of Bifeprunox, contributing to its pharmacological properties and efficacy.
In addition to its role in the synthesis of Bifeprunox, 7-Amino-5-chloro-2(3H)-benzoxazolone may also be utilized in the development of other pharmaceutical compounds with diverse therapeutic applications. Its versatile chemical structure allows for further functionalization and modification, enabling the design of new drugs with improved pharmacokinetic and pharmacodynamic profiles. As a result, this intermediate holds significant potential for the advancement of drug discovery and the treatment of various medical conditions.

InChI:InChI=1/C7H5ClN2O2/c8-3-1-4(9)6-5(2-3)10-7(11)12-6/h1-2H,9H2,(H,10,11)

Upstream product

• 811810-67-0 5-chloro-7-nitrobenzo[d]oxazol-2(3H)-one 

Downstream Products

• 889884-61-1 C₁₁H₁₂ClN₃O₂ 

Relevant articles and documents

Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition

The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification. and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.