88999-92-2

Basic information

• Product Name: 2-(4-bromophenyl)ethane-1-thiol
• Synonyms: 2-(4-bromophenyl)ethane-1-thiol
• CAS NO: 88999-92-2
• Molecular Weight: 217.129
• Mol File: 88999-92-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)ethane-1-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)ethane-1-thiol(88999-92-2)
• EPA Substance Registry System: 2-(4-bromophenyl)ethane-1-thiol(88999-92-2)

Safety Data

• Hazardous Substances Data: 88999-92-2(Hazardous Substances Data)

Upstream product

• 1746-28-7 1-bromo-4-(2-bromoethyl)benzene 
• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 157254-76-7 C₉H₁₁BrN₂S*BrH 
• 4654-39-1 4-bromophenethanol 
• 253443-13-9 S-[2-(4-bromophenyl)ethyl]thioacetate 

Downstream Products

• 1415676-34-4 C₁₆H₁₇BrN₄O₂S 
• 1415676-56-0 C₁₆H₁₇BrN₄O₃S 
• 524675-12-5 2-(4-iodophenyl)ethyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranoside 
• 524675-10-3 2-(4-bromophenyl)ethyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranoside 

Relevant articles and documents

Decarboxylative Thiolation of Redox-Active Esters to Thioesters by Merging Photoredox and Copper Catalysis

Thioesters and related thiols are critically important to biological systems and also widely employed in the synthesis of pharmaceutically important molecules and polymeric materials. However, known synthetic methods often suffer from the disadvantage of

Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues

In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 μM) was found to be a particularly potent inhibitor of the type B MAO isoform. In an attempt to discover potent MAO inhibitors and to further examine the structure-activity relationships (SAR) of MAO inhibition by 8-sulfanylcaffeine analogues, in the present study a series of 8-[(phenylethyl)sulfanyl]caffeine analogues were synthesized and evaluated as inhibitors of human MAO-A and -B. The results document that substitution on C3 and C4 of the phenyl ring with alkyl groups and halogens yields 8-[(phenylethyl)sulfanyl]caffeine analogues which are potent and selective MAO-B inhibitors with IC50 values ranging from 0.017 to 0.125 μM. The MAO inhibitory properties of a series of 8-sulfinylcaffeine analogues were also examined. The results show that, compared to the corresponding 8-sulfanylcaffeine analogues, the 8-sulfinylcaffeins are weaker MAO-B inhibitors. Both the 8-sulfanylcaffeine and 8-sulfinylcaffeine analogues were found to be weak MAO-A inhibitors. This study also reports the MAO inhibition properties of selected 8-[(phenylpropyl)sulfanyl]caffeine analogues.

Uracil derivatives. IV. Growth-inhibitory activity against L-1210 cells of orotic acid derivatives and synthesis of 1-(β-D-ribofuranosyl)furo[3,4-d]pyrimidine-2,4,7(1H,3H,5H)-trione

5-(Substituted thiomethyl)-6-carbamoyluracils (IIIb-h) and 5-(substituted thiomethyl)-uracils (Va-h) were prepared and their ability to inhibit the growth of L-1210 cells in vitro was examined. The reaction of silylated furo[3,4-d]pyrimidine-2,4,7(1H,3H,5