89-47-4Relevant academic research and scientific papers
Hydromenthoxycarbonylation of isobutylene in the presence of tetrakis(triphenylphosphine)palladium-based catalyst systems
Suerbaev,Chepaikin,Zhaksylykova
, p. 422 - 425 (2013/01/16)
The catalytic activity of the Pd(PPh3)4-TsOH and Pd(PPh3)4-PPh3-TsOH systems in the reaction of isobutylene hydromenthoxycarbonylation with carbon monoxide and l-menthol has been examined. It has been
Hydroxycarbonylation of isobutylene in the presence of the palladium acetylacetonate-triphenylphosphine-p-toluenesulfonic acid catalyst system
Suerbaev,Chepaikin,Zhaksylykova, G. Zh.,Kanybetov,Turkbenov,Abyzbekova
experimental part, p. 206 - 209 (2010/02/28)
The reaction of isobutylene hydroxycarbonylation with carbon monoxide and an alcohol (ethanol, 1-menthol) in the presence of the palladium acetylacetonate-triphenylphosphine-p-toluenesulfonic acid catalytic system was investigated. It was shown that the reaction proceeds regioselectively with the formation of linear products (ethyl isovalerate, 1-menthyl isovalerate). The optimum conditions for running the process were found, at which the yield of the main products is 67-79%.
Method of using a compound of menthol and L-arginine as a preparation for the topical delivery of alprostadil for the treatment of female sexual dysfunction
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, (2008/06/13)
A manual application of a topical clitoral sensitizing compound combination consisting og L-arginine and a cooling agent comprised of Menthol and aplrostadil, wherein the combination is applicable manually to the clitoris
Topical menthol, or a related cooling compound, to induce lubrication
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, (2008/06/13)
Vaginal Lubrication is an important component of a woman's sexual arousal. The other components are vaginal vasocongestion and the establishment of a clitoral erection. The use of menthol or any related cooling compound, topically applied to the clitoris, evokes a reflex vaginal lubrication, via the clitoral nociceptors, the spinal autonomic nerves, and inducing the reflex release of vasoactivepolypeptides adjacent to the vaginal arterioles. The vaginal lubrication can be an effective therapy for atrophic vaginitis, the most common cause of dyspareunia (pain with intercourse).
Methods to treat one or all of the defined etiologies of female sexual dysfunction
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, (2008/06/13)
The U.S. Food and Drug Administration defines the four separate components of Female Sexual Dysfunction (FSD) to be decreased sexual desire, decreased sexual arousal, dyspareunia (pain with intercourse), and persistent difficulty in achieving or inability to achieve orgasm (anorgasmia). To establish a diagnosis of FSD, these components must be associated with personal distress, as determined by the affected woman. A topical combination of menthol/L-arginine and the specific 5-PDE inhibitor vardenafil can be used to treat any of the defined components, or a combination of two or more of the defined components of FSD, as a safe, first-line therapy for FSD.
SYNTHESES BASED ON MONOCARBON MOLECULES. I. SYNTHESIS OF MENTHYL ISOVALERATE BY HYDROCARBALKOXYLATION OF ISOBUTYLENE WITH CARBON MONOXIDE AND MENTHOL IN THE PRESENCE OF PALLADIUM-PHOSPHINE COMPLEXES
Suerbayev, Kh.A.,Tsukanov, I.A.,El'man, A.R.,Zhubanov, K.A.
, p. 1072 - 1074 (2007/10/02)
The kinetics of isobutylene carbalkoxylation with carbon monoxide and menthol in the presence of the catalytic system Pd(OAc)2 + PPh3 + p-CH3C6H4SO3OH was studied.The optimal conditions for the synthesis of menthyl isovalerate, which is the main active component inn validol medicine, were determined.
