890025-84-0Relevant articles and documents
Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
Gimenez, Diana,Phelan, Aoife,Murphy, Cormac D.,Cobb, Steven L.
, p. 4672 - 4676 (2021)
Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that display enhanced antifungal properties and chemical stability under both basic and acidic conditions. The analogues prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity.
DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME
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Paragraph 0172; 0173, (2016/12/22)
The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.