89004-83-1Relevant academic research and scientific papers
Synthesis of Analogues of γ-Aminobutyric Acid. Part 11. Unsaturated and Saturated Tetronic Acid Derivatives
Allan, Robin D.,Johnston, Graham A. R.,Kazlauskas, Rymantas,Tran, Hue W.
, p. 2983 - 2986 (2007/10/02)
5-(2-Aminoethylidene)-4-hydroxyfuran-2(5H)-one (3) and the corresponding reduced 5-(2-aminoethyl) derivative (4) have been synthesised as conformationally restricted analogues of the neurotransmitter GABA.The use of the t-butyl protected reagents bis(t-butoxycarbonyl)amine and 5-ethylidene-4-t-butoxyfuran-2(5H)-one (7b) allowed generation of the required amino compounds under mild acidic deprotection conditions in the final step.
