89024-03-3

Upstream product

• 941-69-5 N-phenyl-maleimide 
• 89023-98-3 3,10-Dihydroxy-1,2-dihydro-cyclobuta[b]anthracene-4,9-dione 
• 77422-59-4 2,3-bis(bromomethyl)-1,4-dihydroxyanthracene-9,10-dione 
• 85-44-9 phthalic anhydride 
• 25060-18-8 2,3-dimethyl quinizarine 
• 608-43-5 2,3-dimethyl-1,4-dihydroxybenzene 
• 89023-95-0 1,2,2a,10a-Tetrahydro-cyclobuta[b]anthracene-3,10-dione 
• 89023-96-1 Acetic acid 10-acetoxy-1,2-dihydro-cyclobuta[b]anthracen-3-yl ester 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 89023-97-2 Acetic acid 10-acetoxy-4,9-dioxo-1,2,4,9-tetrahydro-cyclobuta[b]anthracen-3-yl ester 

Relevant academic research and scientific papers

1,2-Dihydro-3,10-dihydroxycyclobut[b]anthracene-4,9-dione, a key intermediate for 4-demethoxyanthracyclinones

The title compound synthesized in four steps from bicyclo[4.2.0]octane-2,5-dione and o-phthaldehyde undergoes cleanly thermolytic intermolecular Diels-Alder reactions providing a general synthesis of 7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedino

Simple o-Quinodimethane Route to (+/-)-4-Demethoxydaunomycinone

The anthracycline antibiotics daunorubicin and adriamycin are important clinically useful drugs in the treatment of a number of human cancers.The structurally simplified synthetic analogues 4-demethoxydaunorubicin and 4-demethoxyadriamycin show much clinical promise.The synthesis of the corresponding aglycon (+/-)-4-demethoxydaunomycinone from the inexpensive dye intermediate quinizarin, utilizing o-quinodimethane intermediates, is discussed.