890306-83-9

Upstream product

• 69618-95-7 (S)-7-(methoxycarbonyl)-2-methyl-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c] pyrimidin-2-ium iodide 
• 100-51-6 benzyl alcohol 
• 71-00-1 L-histidine 
• 4467-54-3 l-histidine methyl ester dihydrochloride 
• 69614-04-6 S-(+)-7-Methoxycarbonyl-5,6,7,8-tetrahydroimidazo<1,5-c>pyrimidin-5-on 

Downstream Products

• 331-38-4 L-anserine 
• 57519-09-2 (S)-methyl 2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoate 
• 1001011-13-7 N-α-(carbobenzyloxy)-N-α,N-1(τ)-dimethyl-L-histidine methyl ester 
• 1001011-15-9 N-α-(carbobenzyloxy)-N-α-propyl,N-1(τ)-methyl-L-histidine methyl ester 
• 1001011-14-8 N-α-(carbobenzyloxy)-N-α-ethyl,N-1(τ)-methyl-L-histidine methyl ester 
• 1001011-16-0 N-α-(carbobenzyloxy)-N-α-isopropyl,N-1(τ)-methyl-L-histidine methyl ester 
• 945723-73-9 methanesulfonic acid 2-benzyloxycarbonylamino-3-(1-methyl-1H-imidazol-4-yl)-propyl ester 
• 945723-57-9 3-[1-(methyl)imidazol-4-yl]-(2S)-2-(benzyloxycarbonylamino)propanol 

Relevant academic research and scientific papers

Concise Synthesis of Anserine: Efficient Solvent Tuning in Asymmetric Hydrogenation Reaction

A concise synthesis of anserine and related compounds was accomplished by Et-DuPhos-Rh-catalyzed asymmetric hydrogenation of dehydrohistidine derivatives in 2,2,2-trifluoroethanol, which played a key role in improving the yield and selectivity.

Synthesis of metal-(pentadentate-salen) complexes: Asymmetric epoxidation with aqueous hydrogen peroxide and asymmetric cyclopropanation (salenH 2: N,N′-bis(salicylidene)ethylene-1,2-diamine)

It is known that the rates and stereochemical outcomes of epoxidations and cyclopropanations using a metallosalen (salenH2: N,N′- bis(salicylidene)ethylene-1,2-diamine) complex as catalyst are affected by a trans effect of the apical ligand of the complex. By taking into consideration this trans effect, we have synthesized optically active pentadentate salen ligands bearing an imidazole or pyridine derivative as the fifth coordinating group, and have prepared the corresponding manganese(III) and cobalt(II) complexes, in which the fifth ligand is expected to intramolecularly coordinate to the metal center and exert a trans effect. Indeed, high enantioselectivity has been achieved in epoxidations using aqueous hydrogen peroxide as the terminal oxidant and in cyclopropanations with these complexes as catalysts. In general, metallosalen-catalyzed reactions have been carried out in the presence of an excess of a donor ligand; however, the present reactions do not need the addition of any extra donor ligand.

Facile regiospecific syntheses of N-α,N-1(τ)-dialkyl-L-histidines

(Chemical Equation Presented) Two diverse methodologies describe the first synthesis of suitably protected N-α,N-1(τ)-dialkyl-L-histidine derivatives. Synthesis of suitably protected N-α,N-1(τ)-dialkyl-L- histidines 7-9 containing different alkyl groups a

Asymmetric epoxidation using aqueous hydrogen peroxide as oxidant: bio-inspired construction of pentacoordinated Mn-salen complexes and their catalysis

Pentacoordinated Mn-salen complexes 1 and 5 possessing an internal pyridine or N-methylimidazole ligand, respectively, were found to be efficient catalysts for asymmetric epoxidation of conjugated Z-olefins using aqueous hydrogen peroxide. In particular,