89033-27-2Relevant academic research and scientific papers
Synthesis method of multi-configuration 2-oxooxazolidine-4-carboxylic acid compound
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Paragraph 0048-0050; 0052-0055, (2020/11/01)
The invention relates to a synthesis method of a multi-configuration 2-oxooxazolidine-4-carboxylic acid compound, wherein the synthesis method comprises the following steps: (1) under the protection of inert gas, carrying out a reaction on a compound represented by a formula I or an isomer thereof with S,S'-dimethyl dithiocarbonate in the presence of water to obtain a compound represented by a formula II or an isomer thereof; (2) carrying out hydrolysis reaction on the compound represented by the formula II or the isomer thereof under an alkaline condition to prepare a compound represented bya formula III or an isomer thereof, wherein the structural formula of the compound represented by the formula I is shown in the specification, the structural formula of the compound represented by theformula II is shown in the specification, the structural formula of the compound represented by the formula III is shown in the specification, in the formula I, the formula II and the formula III, Ris one of H and alkyl with 1-5 carbon atoms. According to the method, water is used as a solvent, so that the method is green, environment-friendly, high in safety, easy in reaction operation and easyin reaction condition control, and the product yield is up to 86% or above.
Quinoline-based compound and selective androgen receptor agonist comprising the same
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Paragraph 0248-0250, (2016/10/08)
Provided are a novel quinoline-based compound, a pharmaceutical composition containing the quinoline-based compound, and a method for producing the quinoline-based compound. The quinoline-based compound acts on an androgen receptor to increase activities of the androgen receptor, and thus can be favorably used as an agent for treating and preventing diseases or conditions, in which the increased activities of the androgen can lead to improvement of symptoms or the responsiveness to treatment, for example, various hormone-related diseases of the male or female, muscle-wasting disease, osteoporosis, and the like.COPYRIGHT KIPO 2016
