890405-51-3

Basic information

• Product Name: 3BDO
• Synonyms: 3BDO;3BDO, 97%, Activator for mTOR, Autophagy inhibitor
• CAS NO: 890405-51-3
• Molecular Formula: C18H17NO5
• Molecular Weight: 327.33128
• Mol File: 890405-51-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3BDO(CAS DataBase Reference)
• NIST Chemistry Reference: 3BDO(890405-51-3)
• EPA Substance Registry System: 3BDO(890405-51-3)

Safety Data

• Hazardous Substances Data: 890405-51-3(Hazardous Substances Data)

Usage

Uses

3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.

Biochem/physiol Actions

3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.