890415-79-9Relevant academic research and scientific papers
Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors
Sano, Hiroko,Noguchi, Tomomi,Miyajima, Atsushi,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 3068 - 3072 (2008/09/20)
Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).
