89047-06-3Relevant articles and documents
Traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines using polystyrene-supported vinyl selenide
Sheng, Shou-Ri,Xin, Qin,Liu, Xiao-Ling,Sun, Wu-Kang,Guo, Rui,Huang, Xian
, p. 2293 - 2296 (2008/02/02)
A novel facile procedure for the traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines in good yields and with excellent purities using polymer-supported vinyl selenide is described. The polymeric reagent can be
SYNTHESIS OF 3-ARYL-4,5-DIHYDRO-5-HYDROXY-1,2-OXAZOLES BY REACTION OF SUBSTITUTED BENZONITRILE OXIDES WITH THE ENOLATE ION OF ACETALDEHYDE.
Di Nunno, L.,Scilimati, A.
, p. 2181 - 2190 (2007/10/02)
By reaction of substituted benzonitrile oxides with the enolate ion of acetaldehyde (quantitatively generated by the known cycloreversion of THF in the presence of n-butyllithium) a number of 3-aryl-4,5-dihydro-5-hydroxy-1,2-oxazoles (previously unknown or, in two cases, only synthesized by different procedures) have been isolated in high yields.Treatment of such hydroxy-isoxalines with some common bases allows their conversion in high yields into the corresponding isoxazoles.