89047-06-3Relevant academic research and scientific papers
Traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines using polystyrene-supported vinyl selenide
Sheng, Shou-Ri,Xin, Qin,Liu, Xiao-Ling,Sun, Wu-Kang,Guo, Rui,Huang, Xian
, p. 2293 - 2296 (2008/02/02)
A novel facile procedure for the traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines in good yields and with excellent purities using polymer-supported vinyl selenide is described. The polymeric reagent can be
One-Pot Synthesis of 3-Substituted Isoxazoles from Phenyl Vinylic Selenide
Sheng, Shou-Ri,Liu, Xiao-Ling,Xu, Qu,Song, Cai-Sheng
, p. 2763 - 2764 (2007/10/03)
Phenyl vinylic selenide was adopted for 1,3-dipolar cycloaddition to nitrile oxides and subsequent oxidation-elimination furnished 3-substituted isoxazoles with good yields in a one-pot, two-step transformation.
SYNTHESIS OF 3-ARYL-4,5-DIHYDRO-5-HYDROXY-1,2-OXAZOLES BY REACTION OF SUBSTITUTED BENZONITRILE OXIDES WITH THE ENOLATE ION OF ACETALDEHYDE.
Di Nunno, L.,Scilimati, A.
, p. 2181 - 2190 (2007/10/02)
By reaction of substituted benzonitrile oxides with the enolate ion of acetaldehyde (quantitatively generated by the known cycloreversion of THF in the presence of n-butyllithium) a number of 3-aryl-4,5-dihydro-5-hydroxy-1,2-oxazoles (previously unknown or, in two cases, only synthesized by different procedures) have been isolated in high yields.Treatment of such hydroxy-isoxalines with some common bases allows their conversion in high yields into the corresponding isoxazoles.
SYNTHESIS AND PROPERTIES OF AZOLS AND THEIR DERIVATIVES. PART VI. CYCLOADDITION REACTIONS OF NITROETHYLENE WITH AROMATIC NITRILE N-OXIDES AND SOME CONVERSIONS OF 3-ARYL-5-NITRO-4,5-DIHYDRO-1,2-OXAZOLES
Baranski, Andrzej,Shvekhgeimer, Genrikh A.
, p. 459 - 467 (2007/10/02)
Reactions of aromatic nitrile N-oxides with nitroethylene lead to formation of 3-aryl-5-nitro-4,5-dihydro-1,2-oxazoles.During heating the above compounds decompose with elimination of nitrous acid, thus affording 3-aryl-1,2-oxazoles.Under nucleophilic reagents a ring opening was observed.
