89059-37-0Relevant articles and documents
Stable isotope labeled zearalenone and synthesis method thereof
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Paragraph 0040-0041;0082, (2021/06/22)
The invention discloses stable isotope labeled zearalenone and a synthesis method thereof. The method comprises the following steps: by taking stable isotope C-labeled benzene-C6 as a starting raw material, carrying out nitration reaction, nitro reduction reaction, benzene ring bromination reaction, amino elimination reaction, methoxylation reaction, aldehyde group oxidation reaction and demethylation reaction to obtain stable isotope C-labeled 2, 4, 6-trihydroxybenzoic acid-benzene ring-C6, and then carrying out lactonization reaction of hydroxyl and carboxyl, methyl reaction in Mitsunobu reaction, Stille reaction, reaction of oxidizing hydroxyl into aldehyde group, esterification reaction of carboxylic acid and alcohol, reaction of oxidizing hydroxyl into ketone carbonyl group, olefin metathesis reaction, olefin selective reduction reaction and the like. According to the invention, stable isotope labeled zearalenone-benzene ring-6 is obtained through a total synthesis method for the first time, raw materials are cheap and easy to obtain, reaction products in all steps are easy to separate and purify, the yield is high, and the chemical purity and the stable isotope abundance both reach 98% or above.
Synthetic method of erlotinib-C6
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Paragraph 0013, (2020/06/09)
The invention provides a synthesis method of erlotinib-C6, which comprises the following steps: 1) carrying out a nitration reaction on a compound 1 and ammonium nitrate to obtain a compound 2; 2)adding sodium periodate and potassium iodide into conce
Synthesis of stable isotope–labeled chloroquine and amodiaquine and their metabolites
Wu, Ruilian,Williams, Robert F.,Silks, L.A. “Pete”,Schmidt, Jurgen G.
, p. 230 - 248 (2019/05/24)
Anti-malaria drugs chloroquine and amodiaquine and their metabolites were synthesized to incorporate 13C and 15N starting from U-13C–labeled benzene to give M?+?7 isotopomers. Chloroquine and its metabolites were prepared
The synthesis of labelled forms of saquinavir
Wiltshire,Prior,Dhesi,Trach,Schlageter,Schoenenberger
, p. 1103 - 1126 (2007/10/03)
The development of the HIV-protease inhibitor, saquinavir (Ro 31-8959), required a range of analytical methods for the measurement of the parent drug and drug-related material in biological fluids. This paper describes the synthesis of 14-carbon and tritium labelled compounds used for in vivo and in vitro investigations of the absorption and disposition of saquinavir in animals and man. It also discusses the preparation of saquinavir labelled with deuterium and stable isotopes of carbon and nitrogen. These forms of the drug were needed for bioequivalence studies in which HPLC/MS/MS was employed for the measurement of plasma concentrations. Finally, the synthesis of a 125-iodine labelled tracer used in a radioimmunoassay for saquinavir is described.
DETERMINATION OF 3,3',4,4'-TETRACHLOROAZOBENZENE IN WATER BY ISOTOPE DILUTION GAS CHROMATOGRAPHY/HIGH RESOLUTION MASS SPECTROMETRY
Schneider, Serge,Hashimoto, Shunji,Yamamoto, Takashi,Morita, Masatoshi
, p. 81 - 88 (2007/10/03)
A methodology, based on gas chromatography/high resolution mass spectrometry selected ion monitoring (GC/HRMS SIM) has been developed for the determination of 3,3',4,4'-tetrachloro-azobenzene (TCAB), a potential carcinogen, in water. As internal standard we prepared labelled TCAB, from labelled benzene. TCAB was extracted from water by hexane followed by a cleanup column chromatography over basic alumina. Recoveries of TCAB range from 80.0-88.3 percent. The detection limit of TCAB is about 50 fg of TCAB or 5 ppq in 1,000 mL of water.
