89059-57-4Relevant academic research and scientific papers
Synthesis of 3,5-Diaryl-6-carbethoxycyclohex-2-en-1-ones and 4,6-Diaryl-3,3a,4,5-tetrahydro-3(2H)-oxoindazoles and a Study of their Biological Activities
Jain, A. C.,Arya, Prabhat
, p. 645 - 648 (2007/10/02)
Four different chalcones (1a-d) have been subjected to Michael condensation with ethyl acetoacetate in the presence of either ethanolic piperidine or dry potassium carbonate in acetone and the resultant 3,5-diaryl-6-carbethoxy-cyclohex-2-en-1-ones (2a-d) converted into the corresponding 4,6-diaryl-3,3a,4,5-tetrahydro-3(2H)-oxoindazoles (3a-d) by heating with hydrazine hydrate in ethanolic acetic acid.These products have been characterised as acetates which are shown to exist as mixtures of 4a-d and 5a-d on the basis of their PMR data.The biological activities of 3a-d are also discussed.
A STUDY OF THE MICHAEL REACTION OF 2'-HYDROXYCHALCONES AND A FACILE FORMATION OF 4H-PYRAN DERIVATIVES
Jain, Amolak Hand,Arya, Prabhat,Sharma, Anita
, p. 2369 - 2378 (2007/10/02)
2'-Hydroxychalcones (8a) and (8b) when subjected to the Michael reaction with acetyl acetone in the presence of ethanolic piperidine gave the 4H-pyran derivatives (9a) and (9b) besides the cyclohexenone derivatives (10a and 11a) and (10b and 11b) respectively.However, 8c yielded under the same conditions only the 4H-pyran derivative (9c) together with some 5,7-dimethoxyflavanone (12c).Thus 4H-pyrans have, for the first time, been characterized during Michael condensation of chalcones having no electron withdrawing group in the α-position.Ethyl acetoacetate gives only cyclohexenone derivatives.
