890591-72-7 Usage
Uses
Used in Medicinal Chemistry:
5-CYCLOPROPYL-2H-PYRAZOLE-3-CARBOXYLIC ACID is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic properties.
Used in Chemical Research:
5-CYCLOPROPYL-2H-PYRAZOLE-3-CARBOXYLIC ACID is used as a tool in chemical research to study its biological activities and explore its potential applications in various fields.
Used in Pharmaceutical Industry:
5-CYCLOPROPYL-2H-PYRAZOLE-3-CARBOXYLIC ACID is used as a key intermediate in the synthesis of drugs with potential therapeutic benefits.
Used in Agrochemical Industry:
5-CYCLOPROPYL-2H-PYRAZOLE-3-CARBOXYLIC ACID is used as a precursor in the development of agrochemicals for crop protection and enhancement of agricultural productivity.
Check Digit Verification of cas no
The CAS Registry Mumber 890591-72-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,5,9 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 890591-72:
(8*8)+(7*9)+(6*0)+(5*5)+(4*9)+(3*1)+(2*7)+(1*2)=207
207 % 10 = 7
So 890591-72-7 is a valid CAS Registry Number.
890591-72-7Relevant academic research and scientific papers
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a
Skinner, Philip J.,Cherrier, Martin C.,Webb, Peter J.,Shin, Young-Jun,Gharbaoui, Tawfik,Lindstrom, Andrew,Hong, Vu,Tamura, Susan Y.,Dang, Huong T.,Pride, Cameron C.,Chen, Ruoping,Richman, Jeremy G.,Connolly, Daniel T.,Semple, Graeme
, p. 5620 - 5623 (2008/04/02)
A series of 5-alkyl pyrazole-3-carboxylic acids were prepared and found to act as potent and selective agonists of the human GPCR, GPR109a, the high affinity nicotinic acid receptor. No activity was observed at the highly homologous low affinity niacin receptor, GPR109b. A further series of 4-fluoro-5-alkyl pyrazole-3-carboxylic acids were shown to display similar potency. One example from the series was shown to have improved properties in vivo compared to niacin.
