890643-16-0 Usage
Uses
Used in Paints and Coatings Industry:
DC05 is used as a dispersing agent for improving the uniform distribution of pigments and fillers in paint formulations, enhancing the quality and performance of the final product.
Used in Inks Industry:
DC05 is used as a dispersing agent to ensure the even dispersion of colorants and other solid particles in ink formulations, contributing to consistent ink performance and print quality.
Used in Adhesives Industry:
DC05 is used as a dispersing agent to promote the uniform distribution of solid additives in adhesive formulations, which can improve the adhesive's bonding strength and durability.
Used in Emulsions and Suspensions Manufacturing:
DC05 is used as a stabilizer to prevent the settling of particles in emulsions and suspensions, maintaining product stability and performance over time.
Used in Eco-friendly and Sustainable Solutions:
DC05 is utilized as a low toxicity and environmentally friendly chemical additive in various industrial formulations, catering to the market demand for sustainable products.
Check Digit Verification of cas no
The CAS Registry Mumber 890643-16-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,6,4 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 890643-16:
(8*8)+(7*9)+(6*0)+(5*6)+(4*4)+(3*3)+(2*1)+(1*6)=190
190 % 10 = 0
So 890643-16-0 is a valid CAS Registry Number.
890643-16-0Relevant articles and documents
Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening
Chen, Shijie,Wang, Yulan,Zhou, Wen,Li, Shanshan,Peng, Jianlong,Shi, Zhe,Hu, Junchi,Liu, Yu-Chih,Ding, Hong,Lin, Yijyun,Li, Linjuan,Cheng, Sufang,Liu, Jingqiu,Lu, Tao,Jiang, Hualiang,Liu, Bo,Zheng, Mingyue,Luo, Cheng
, p. 9028 - 9041 (2014)
The DNA methyltransferases (DNMTs) found in mammals include DNMT1, DNMT3A, and DNMT3B and are attractive targets in cancer chemotherapy. DNMT1 was the first among the DNMTs to be characterized, and it is responsible for maintaining DNA methylation patterns. A number of DNMT inhibitors have been reported, but most of them are nucleoside analogs that can lead to toxic side effects and lack specificity. By combining docking-based virtual screening with biochemical analyses, we identified a novel compound, DC-05. DC-05 is a non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases. Through a process of similarity-based analog searching, compounds DC-501 and DC-517 were found to be more potent than DC-05. These three potent compounds significantly inhibited cancer cell proliferation. The structure-activity relationship (SAR) and binding modes of these inhibitors were also analyzed to assist in the future development of more potent and more specific DNMT1 inhibitors.
