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890655-08-0

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890655-08-0 Usage

Description

Cetilistat Intermediate is a chemical compound that serves as a key intermediate in the synthesis of the pharmaceutical drug cetilistat, a medication designed for weight loss. It is an essential component in the manufacturing process of cetilistat, contributing significantly to the drug's effectiveness as a weight management treatment.

Uses

Used in Pharmaceutical Industry:
Cetilistat Intermediate is used as a crucial component in the production of cetilistat, a weight loss medication. It plays a significant role in the development of this medication, ensuring its effectiveness in managing weight.
Cetilistat Intermediate is used as an intermediate in the synthesis of cetilistat for its weight loss properties, as it inhibits the enzyme lipase, which is responsible for breaking down dietary fat in the intestine. This inhibition prevents the absorption of fat, thereby aiding in weight reduction.

Check Digit Verification of cas no

The CAS Registry Mumber 890655-08-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,6,5 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 890655-08:
(8*8)+(7*9)+(6*0)+(5*6)+(4*5)+(3*5)+(2*0)+(1*8)=200
200 % 10 = 0
So 890655-08-0 is a valid CAS Registry Number.

890655-08-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Benzoic acid, 2-[[(hexadecyloxy)carbonyl]amino]-5-methyl-

1.2 Other means of identification

Product number -
Other names Cetilistat Intermediate of Cetilistat

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:890655-08-0 SDS

890655-08-0Relevant articles and documents

NOVEL PROCESSES FOR THE PREPARATION OF 2-OXY-BENZOXAZINONE DERIVATIVES

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Page/Page column 17, (2018/02/28)

Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of 2-hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one, and its intermediates, in high yield and purity.

Preparation method of cetilistat

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Paragraph 0051; 0052; 0053, (2016/10/09)

The invention discloses a preparation method of cetilistat; the method has the advantages of concise process, easily obtained raw materials, and mild reaction conditions, and is suitable for industrialized production. According to a reaction route, 2-amino-5-methyl benzoic acid and hexadecyl chloroformate serve as starting raw materials, firstly, amino acylation is carried out, an intermediate is purified, then cyclization is carried out, and the target compound is obtained through a two-step reaction.

Method for preparing cetilistat

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Paragraph 0047; 0048; 0049; 0050; 0051; 0052; 0053, (2016/12/12)

The invention provides a method for preparing cetilistat. According to the method, 2-amidogen-5-methyl benzoic acid is adopted as an initial raw material, under existence of pyridine, the 2-amidogen-5-methyl benzoic acid reacts with chlorine acid cetyl alcohol ester in the first place, a midbody 2-(((hexadecane oxygroup) carbonyl) amidogen)-5-methyl benzoic acid is obtained, then dehydrogenation cyclization reagent is utilized to obtain the cetilistat, and the feeding sequence in step 1 is the 2-amidogen-5-methyl benzoic acid, alkali and the chlorine acid cetyl alcohol ester in sequence. The method has the remarkable advantages that the route is simple, operation is less, atom economy is better than that of other routes, and the cetilistat is suitable for large-scale production; the purity of the cetilistat at the reaction endpoint is larger than 98%, and through simple postprocessing, a final product which meets medical standards can be obtained, wherein the purity is larger than 99.5%, and the single impurity is smaller than 0.1%; the utilized solvent including dichloromethane and pyridine can be recycled for mechanical application, and the method is environmentally friendly.

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