890657-16-6

Upstream product

• 143262-10-6 1-(tert-butoxycarbonyl)indoline 
• 890657-11-1 tert-butyl 7-(2-oxocyclohexyl)indoline-1-carboxylate 
• 33948-36-6 2-iodocyclohex-2-en-1-one 
• 890657-09-7 tert-butyl 7-(6-oxocyclohex-1-enyl)-indoline-1-carboxylate 
• 890657-14-4 tert-butyl 7-(2-(trifluoromethylsulfonyloxy)cyclohex-1-enyl)indoline-1-carboxylate 

Relevant academic research and scientific papers

Indole diterpene synthetic studies: Development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B

(Chemical Equation Presented) A second-generation strategy for construction of (+)-nodulisporic acids A and B based on the development of a new, effective modular indole synthesis exploiting a sequential Stille cross-coupling/Buchwald- Hartwig union/cyclization tactic is disclosed. This strategy evolved due to the considerable acid instability of the C(24) hydroxyl group observed in several advanced intermediates during our first-generation approach.

A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B

Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns.