890657-16-6Relevant articles and documents
Indole diterpene synthetic studies: Development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B
Smith III, Amos B.,Kuerti, Laszlo,Davulcu, Akin H.,Young, Shin Cho,Ohmoto, Kazuyuki
, p. 4611 - 4620 (2008/02/07)
(Chemical Equation Presented) A second-generation strategy for construction of (+)-nodulisporic acids A and B based on the development of a new, effective modular indole synthesis exploiting a sequential Stille cross-coupling/Buchwald- Hartwig union/cyclization tactic is disclosed. This strategy evolved due to the considerable acid instability of the C(24) hydroxyl group observed in several advanced intermediates during our first-generation approach.