890657-57-5Relevant academic research and scientific papers
Increasing appendage diversity on 3,4-dihydro-3-oxo-2H-1,4-benzoxazines via Aphos-Pd(OAc)2-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides
Yu, Gongli,Zheng, Yu,Wu, Jinlong,Dai, Wei-Min
, p. 10488 - 10496 (2013)
A library of 32 members of 3,4-dihydro-3-oxo-2H-1,4-benzoxazines has been synthesized from two substituted 2-aminophenols via microwave-assisted one-pot regioselective annulation of 2-bromoalkanoates and subsequent Suzuki-Miyaura cross-coupling of the chloro-substituted scaffolds. The latter transformation was carried out using our Aphos-Pd(OAc)2 catalyst and the coupling of the aryl chlorides with arylboronic acids proceeded under mild reaction conditions at 60-80 C in THF-H2O (10:1) in the presence of K 3PO4·3H2O as the base to furnish the corresponding biaryl products in 80-98% yields.
One-pot regioselective annulation toward 3,4-dihydro-3-oxo-2H-1,4-benzoxazine scaffolds under controlled microwave heating
Feng, Gaofeng,Wu, Jinlong,Dai, Wei-Min
, p. 4635 - 4642 (2007/10/03)
An efficient and general synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines under controlled microwave heating has been established. It consists of a microwave-assisted reductive N-arylmethylation of substituted 2-aminophenols with aromatic aldehy
