890839-47-1 Usage
Uses
Used in Pharmaceutical Development:
8-Bromo-6-chloro-2,3-dihydro-4H-chromen-4-one is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Drug Discovery:
8-Bromo-6-chloro-2,3-dihydro-4H-chromen-4-one is utilized in drug discovery processes to identify novel bioactive molecules. Its chemical properties and structural features make it a valuable tool in the search for new therapeutic agents.
Used in Organic Chemistry Research:
8-Bromo-6-chloro-2,3-dihydro-4H-chromen-4-one serves as a subject of study in organic chemistry, where its reactivity, synthesis, and potential reactions with other compounds are explored.
Used in Biochemistry Studies:
In biochemistry, 8-Bromo-6-chloro-2,3-dihydro-4H-chromen-4-one is used to investigate its interactions with biological systems, including potential binding to enzymes or receptors, which could lead to the discovery of new biological activities.
While the specific uses and potential functions of 8-Bromo-6-chloro-2,3-dihydro-4H-chromen-4-one are still being explored, its presence in the realm of medicinal chemistry suggests a broad range of applications that could be uncovered through continued research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 890839-47-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,8,3 and 9 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 890839-47:
(8*8)+(7*9)+(6*0)+(5*8)+(4*3)+(3*9)+(2*4)+(1*7)=221
221 % 10 = 1
So 890839-47-1 is a valid CAS Registry Number.
890839-47-1Relevant academic research and scientific papers
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists
Schmidt, Robert G.,Bayburt, Erol K.,Latshaw, Steven P.,Koenig, John R.,Daanen, Jerome F.,McDonald, Heath A.,Bianchi, Bruce R.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Marsh, Kennan C.,Lee, Chih-Hung,Faltynek, Connie R.,Gomtsyan, Arthur
scheme or table, p. 1338 - 1341 (2011/04/23)
Novel chroman and tetrahydroquinoline ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that aryl substituents on the 7- or 8-position of both bicyclic scaffolds imparted the best in vitro potency at TRPV1. The most potent chroman ureas were assessed in chronic and acute pain models, and compounds with the ability to cross the blood-brain barrier were shown to be highly efficacious. The tetrahydroquinoline ureas were found to be potent CYP3A4 inhibitors, but replacement of bulky substituents at the nitrogen atom of the tetrahydroisoquinoline moiety with small groups such as methyl can minimize the inhibition.
Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof
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Page/Page column 22, (2008/06/13)
Compounds that are antagonists of the VR1 receptor, having formula (I) [image] or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
