890844-46-9

Basic information

• Product Name: [2-(4-bromophenyl)-2-methylpropoxy](tert-butyl)dimethylsilane
• Synonyms: [2-(4-bromophenyl)-2-methylpropoxy](tert-butyl)dimethylsilane
• CAS NO: 890844-46-9
• Molecular Weight: 343.379
• Mol File: 890844-46-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: [2-(4-bromophenyl)-2-methylpropoxy](tert-butyl)dimethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-bromophenyl)-2-methylpropoxy](tert-butyl)dimethylsilane(890844-46-9)
• EPA Substance Registry System: [2-(4-bromophenyl)-2-methylpropoxy](tert-butyl)dimethylsilane(890844-46-9)

Safety Data

• Hazardous Substances Data: 890844-46-9(Hazardous Substances Data)

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 32454-37-8 2,2-dimethyl-2-(4-bromophenyl)ethanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1467058-08-7 6-chloro-5-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-1H-indole-3-carboxylic acid 
• 1467060-67-8 5-[4-(1-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpropan-2-yl)phenyl]-6-chloro-1H-indole-3-carboxylic acid 
• 1467060-66-7 5-[4-(1-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpropan-2-yl)phenyl]-6-chloro-1H-indole-3-carbaldehyde 
• 1467057-80-2 4,6-difluoro-5-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-1H-indole-3-carboxylic acid 
• 1467060-50-9 4,6-difluoro-5-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-1H-indole-3-carbaldehyde 
• 1467060-49-6 2-[4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]-2-methylpropan-1-ol 
• 32454-37-8 2,2-dimethyl-2-(4-bromophenyl)ethanol 
• 1467059-13-7 6-chloro-5-(4-(1-hydroxy-2-methylpropan-2-yl)phenyl)-1H-indazole-3-carboxylic acid 
• 1322094-75-6 C₂₂H₃₉BO₃Si 

Relevant articles and documents

NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND

There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action: wherein Ring A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group, RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula -CR11R12-, -CO-, -CO-O-, or -CO-NH-, W represents a single bond or a C1-3 alkylene group, and Ring B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group, Y represents a nitrogen atom or the formula N+(RF), RF represents a C1-4 alkyl group, and m and n, which may be the same or different, each represent an integer of 0 or 1.

Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide

Analogues related to dirlotapide (1), a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) were prepared with the goal of further reducing the potential for unwanted liver MTP inhibition and associated side-effects. Compounds were designed to decrease active metabolite load: reducing MTP activity of likely human metabolites and increasing metabolite clearance to reduce exposure. Introduction of 4′-alkyl and 4′-alkoxy substituents afforded compounds exhibiting improved therapeutic index in rats with respect to liver triglyceride accumulation and enzyme elevation. Likely human metabolites of select compounds were prepared and characterized for their potential to inhibit MTP in vivo. Based on preclinical efficacy and safety data and its potential for producing short-lived, weakly active metabolites, compound 13 (PF-02575799) advanced into phase 1 clinical studies.

12-ARYL PROSTAGLANDIN ANALOGS

Compounds comprising the formula (I) are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the ω-chain comprises a substituted phenyl, wherein at least one substituent