89088-69-7

Basic information

• Product Name: 1-Methyl-1H-iMidazol-4-aMine hydrochloride
• Synonyms: 1-Methyl-1H-iMidazol-4-aMine hydrochloride;1-Methyl-1H-imidazol-4-amine monohydrochloride;1H-IMidazol-4-aMine, 1-Methyl-, Monohydrochloride;NC1=CN(C)C=N1.[H]Cl;1-METHYL-1H-IMIDAZOL-4-AMINE HCL
• CAS NO: 89088-69-7
• Molecular Formula: C₄H₇N₃*ClH
• Molecular Weight: 133.57942
• Mol File: 89088-69-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-Methyl-1H-iMidazol-4-aMine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-iMidazol-4-aMine hydrochloride(89088-69-7)
• EPA Substance Registry System: 1-Methyl-1H-iMidazol-4-aMine hydrochloride(89088-69-7)

Safety Data

• Hazardous Substances Data: 89088-69-7(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-imidazol-4-amine hydrochloride is a chemical compound used in the laboratory research of drug development and neuroscience. It is an organic compound that is commonly used as a building block in the synthesis of pharmaceuticals and other biologically active compounds. This chemical has a wide range of applications, including its use as a precursor for the synthesis of various drugs, and as a reagent in chemical reactions. It is also used in the study of central nervous system disorders and the development of new treatment options. Overall, 1-methyl-1H-imidazol-4-amine hydrochloride is an important and versatile chemical compound with many research and industrial applications.

Upstream product

• 3034-41-1 1-methyl-4-nitro-1H-imidazole 
• 79578-98-6 1-methyl-1H-imidazol-4-amine 

Downstream Products

• 1220517-76-9 2-chloro-N-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1220517-78-1 2-chloro-N-(1-methyl-1H-imidazol-4-yl)-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine 

Relevant articles and documents

Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors

Herein, we report the discovery and characterization of a novel class of PAK4 inhibitors with a quinazoline scaffold. Based on the shape and chemical composition of the ATP-binding pocket of PAKs, we chose a 2,4-diaminoquinazoline series of inhibitors as a starting point. Guided by X-ray crystallography and a structure-based drug design (SBDD) approach, a series of novel 4-aminoquinazoline-2-carboxamide PAK4 inhibitors were designed and synthesized. The inhibitors' selectivity, therapeutic potency, and pharmaceutical properties were optimized. One of the best compounds, 31 (CZh226), showed remarkable PAK4 selectivity (346-fold vs PAK1) and favorable kinase selectivity profile. Moreover, this compound potently inhibited the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro. Taken together, these data support the further development of 31 as a lead compound for PAK4-targeted anticancer drug discovery and as a valuable research probe for the further biological investigation of group II PAKs.

HETEROCYCLIC JAK KINASE INHIBITORS

The present invention relates to compounds of Formula (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer