89100-18-5Relevant articles and documents
Enantioselective Palladium-Catalyzed Decarboxylative Allylation of β-Keto Esters Assisted by a Thiourea
Qian, Hua,Gu, Guoxian,Zhou, Qinghai,Lu, Jiaxiang,Chung, Lung Wa,Zhang, Xumu
, p. 51 - 56 (2017/10/06)
Enantioselective intramolecular decarboxylative allylation of β-keto esters catalyzed by a palladium bis(phosphine)-thiourea complex is reported. This procedure is not only effective for β-keto esters, but also effective for β-keto amides. An intermolecular variant of the asymmetric decarboxylative allylation is also established. DFT calculations indicate that an outer-sphere mechanism is viable for the decarboxylative allylation of β-keto esters.