89104-48-3 Usage
Uses
Used in Pharmaceutical Research:
(4R,5R)-2-CHLORO-4,5-DIMETHYL-1,3,2-DIOXAPHOSPHOLANE 2-OXIDE is used as a chiral building block for the synthesis of various pharmaceuticals and agrochemicals. Its specific configuration allows for the creation of enantiomerically pure compounds, which is crucial for the development of drugs with targeted biological activity.
Used in Asymmetric Catalysis:
In the field of catalysis, (4R,5R)-2-CHLORO-4,5-DIMETHYL-1,3,2-DIOXAPHOSPHOLANE 2-OXIDE is used as a ligand to facilitate enantioselective reactions. This application is valuable for producing chiral molecules with specific biological activity, ensuring that the desired enantiomer is selectively formed during the synthesis process.
Used in Organic Synthesis:
(4R,5R)-2-CHLORO-4,5-DIMETHYL-1,3,2-DIOXAPHOSPHOLANE 2-OXIDE is also utilized in organic synthesis for the preparation of complex organic molecules. Its unique structure and reactivity make it a versatile intermediate for the construction of a wide range of compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 89104-48-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,1,0 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 89104-48:
(7*8)+(6*9)+(5*1)+(4*0)+(3*4)+(2*4)+(1*8)=143
143 % 10 = 3
So 89104-48-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H8ClO3P/c1-3-4(2)8-9(5,6)7-3/h3-4H,1-2H3/t3-,4-/m1/s1
89104-48-3Relevant academic research and scientific papers
Chemistry of β-(phosphatoxy)alkyl and β-(acyloxy)alkyl radicals. Migration reactions: Scope and stereoselectivity of β-(phosphatoxy)alkyl rearrangement. Mechanism of β-(phosphatoxy)alkyl and β-(acyloxy)alkyl migration
Crich, David,Yao, Qingwei,Filzen, G. Fredrick
, p. 11455 - 11470 (2007/10/03)
An in depth study of the mechanism of the β-(phosphatoxy)alkyl radical migration is presented. Examples are presented which define the scope and limitations of the migration and show that, in certain cases, it is highly stereoselective. It is shown that phosphoranyl radicals are not intermediates in this rearrangement. A series of experiments with stereochemically-, 18O-, and deuterium-labeled probes indicate that the migration is intramolecular, proceeds through competing 1,2- and 2,3-pathways, and does not involve fragmentation to a cage pair followed by recombination. The deuterium-labeled probe is also applied to the β-(acyloxy)alkyl migration with the same result. The changing proportions of 1,2- and 2,3-shifts in going from the β-(phosphatoxy)alkyl to the β-(acyloxy)alkyl migration are discussed in terms of the conformational equilibria of the two different esters and the Curtin-Hammett principle.
