89110-18-9Relevant academic research and scientific papers
New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: Synthesis, resolution, and inhibitory activity
Krajewski, Krzysztof,Zhang, Yijun,Parrish, Damon,Deschamps, Jeffrey,Roller, Peter P.,Pathak, Vinay K.
, p. 3034 - 3038 (2008/12/21)
We synthesized, separated into enantiomers, and tested for the HIV-1 reverse transcriptase inhibitory activity a group of analogs of dimethyl-1-(1-piperidynyl)cyclobuta[b][1]benzothiophene-2,2a(7bH)-dicarboxylate (NSC-380292). Absolute configurations of the enantiomers were determined based on absolute X-ray structures and analysis of CD spectra. Within pairs of enantiomers the (R,R)-enantiomer was always much more potent HIV-1 reverse transcriptase inhibitor.
REACTION OF 2-(1-PYRROLIDINYL)BENZOTHIOPHENE WITH DIMETHYL ACETYLENEDICARBOXYLATE; THE FIRST EXAMPLE OF THE THERMAL REARRANGEMENT OF A 2-THIABICYCLOHEPTA-3,6-DIENE
Visser, G. W.,Verboom, W.,Reinhoudt, D. N.
, p. 498 - 499 (2007/10/02)
Reaction of 2-(1-pyrrolidinyl)benzothiophene with dimethyl acetylenedicarboxylate gives the unexpected isomeric (2+2)-cycloadduct 3 in a yield of 75 percent.
