891115-94-9

Basic information

• Product Name: 1-(4-NITROPHENYL)-1-(2-THIENYLCARBONYL)THIOSEMICARBAZIDE
• Synonyms: 1-(4-NITROPHENYL)-1-(2-THIENYLCARBONYL)THIOSEMICARBAZIDE;N-{[(4-nitrophenyl)carbamothioyl]amino}thiophene-2-carboxamide
• CAS NO: 891115-94-9
• Molecular Formula: C₁₂H₁₀N₄O₃S₂
• Molecular Weight: 322.36
• Mol File: 891115-94-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-NITROPHENYL)-1-(2-THIENYLCARBONYL)THIOSEMICARBAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-NITROPHENYL)-1-(2-THIENYLCARBONYL)THIOSEMICARBAZIDE(891115-94-9)
• EPA Substance Registry System: 1-(4-NITROPHENYL)-1-(2-THIENYLCARBONYL)THIOSEMICARBAZIDE(891115-94-9)

Safety Data

• Hazardous Substances Data: 891115-94-9(Hazardous Substances Data)

Upstream product

• 2361-27-5 2-thienylhydrazide 
• 2131-61-5 p-nitrophenyl isothiocyanate 

Relevant articles and documents

1,4-disubstituted thiosemicarbazide derivatives are potent inhibitors of toxoplasma gondii proliferation

A series of 4- Arylthiosemicarbazides substituted at the N1 position with a 5-membered heteroaryl ring was synthesized and evaluated in vitro for T. gondii inhibition proliferation and host cell cytotoxicity. At non- Toxic concentrations for the host cells all studied compounds displayed excellent anti-parasitic effects when compared to sulfadiazine, indicating a high selectivity of their anti-T. gondii activity. The differences in bioactivity investigated by DFT calculations suggest that the inhibitory activity of 4- Arylthiosemicarbazides towards T. gondii proliferation is connected with the electronic structure of the molecule. Further, these compounds were tested as potential antibacterial agents. No growth-inhibiting effect on any of the test microorganisms was observed for all the compounds, even at high concentrations.