89116-07-4

Upstream product

• 17996-12-2 N-benzyloxycarbonyl-6-amino-1-hexanol 
• 3068-32-4 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside 
• 3006-60-8 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-galactopyranose 
• 4163-60-4 β-D-galactose peracetate 
• 7296-64-2 β-D-galactopyranoside 

Downstream Products

• 1402413-59-5 1-O-(6-p-(18)F-fluorobenzoylamino-1-hexyl)-β-galactopyranoside 
• 138039-85-7 C₅₅H₇₈N₆O₁₈S 
• 138039-83-5 (D-Met²,Pro⁵)-enkephalin-N-<(β-D-galactopyranosyl)oxyhexyl>amide 
• 201737-15-7 6-benzyloxycarbonylaminohexyl 2,3,4-tri-O-benzoyl-6-O-triphenylmethyl-β-D-galactopyranoside 
• 201737-16-8 6-benzyloxycarbonylaminohexyl 2,3,4-tri-O-benzoyl-β-D-galactopyranoside 
• 201737-14-6 [6-((2R,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-trityloxymethyl-tetrahydro-pyran-2-yloxy)-hexyl]-carbamic acid benzyl ester 
• 201737-12-4 6-benzyloxycarbonylaminohexyl 2-O-acetyl-3-O-benzoyl-6-O-benzyl-β-D-galactopyranoside 
• 201737-11-3 Benzoic acid (4aR,6R,7R,8S,8aS)-7-acetoxy-6-(6-benzyloxycarbonylamino-hexyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 201737-10-2 6-benzyloxycarbonylaminohexyl 3-O-benzoyl-4,6-O-benzylidene-β-D-galactopyranoside 
• 201737-05-5 6-benzyloxycarbonylaminohexyl 4,6-O-benzylidene-β-D-galactopyranoside 
• 201737-04-4 6-benzyloxycarbonylaminohexyl β-D-galactopyranoside 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates

Asialoglycoprotein receptor (ASGP-R) is a promising biological target for drug delivery into hepatoma cells. Nevertheless, there are only few examples of small-molecule conjugates of ASGP-R selective ligand equipped by a therapeutic agent for the treatment of hepatocellular carcinoma (HCC). In the present work, we describe a convenient and versatile synthetic approach to novel mono- and multivalent drug-conjugates containing N-acetyl-2-deoxy-2-aminogalactopyranose and anticancer drug – paclitaxel (PTX). Several molecules have demonstrated high affinity towards ASGP-R and good stability under physiological conditions, significant in vitro anticancer activity comparable to PTX, as well as good internalization via ASGP-R-mediated endocytosis. Therefore, the conjugates with the highest potency can be regarded as a promising therapeutic option against HCC.

18F-Labeled Monomeric Galactose Derivative Used as Tomography Probe

A 18F-labeled monomeric galactose derivative is provided as a tomography probe. The derivative is a positron emission tomography (PET) probe. The derivative has high affinity and good stability in animal's body. The derivative can be an alternative glucose metabolism imaging agent used in clinic examination and quantification.

Synthesis of a set of highly clustered monosulfated galactopyranosides

There are several biological events that are known to involve certain sulfated saccharides. In many such cases, however, clustered ligands have been shown to be more effective than monovalent saccharides. A set of 6-aminohexyl glycosides of 2,3,4 or 6-monosulfated galactose have been synthesized and linked to polyglutamic acid. Because of the bulky aglycon employed, the 2-OH group of the key compound, 6-benzyloxycarbonylaminohexyl 4,6-O-benzylidene-β-D-galactopyranosid was markedly less reactive than 3-OH. Thus, site-specific acetylation of 3-OH was readily carried out to obtain 2-O-sulfated galactosides, and even the direct sulfation of 3-OH afforded the 3-sulfate in a reasonable yield. On the other hand, the key compound was unexpectedly resistant to 2,3-O-dibenzylation or 2,3-O-dibenzoylation, both of which were meant for regioselective cleavage of 4,6-benzylidene to obtain the 4-sulfate.