89124-32-3Relevant academic research and scientific papers
Facile synthesis of [1,2,4]triazino[4,3-b][1,2,4,5]tetrazepin derivatives by a one-pot reactions using 4-amino-3-hydrazinyl-6-methyl-1,2,4-triazin-5(4H)-one
Vahedi, Hooshang,Rajabzadeh, Ghadir,Farvandi, Fahimeh
experimental part, p. 1419 - 1422 (2011/10/09)
4-Amino-3-mercapto-6-methyl-1,2,4-triazin-5(4. H)-one 1 converted to 4-amino-6-methy-3-(methylthio)-1,2,4-triazin-5(4. H)-one by methylation with methyl iodide. Controlled hydrazination of the resulting compound afforded 4-amino-3-hydrazinyl-6-methyl-1,2,4-triazin-5(4. H)-one 2 as a building block, to the synthesis of some novel derivatives of [1,2,4]triazino [4,3,. b][1,2,4,5]tetrazepine 3-6, by the reaction with 3-chloropentane-2,4-dione, chloro acetonitrile, 1,3-dichloroacetone, and methyl bromoacetate. This general synthetic procedure can be extended to the preparation of wide variety of tetrazepines using 1,2-bielectrophiles derivatives.
Triazine compounds and methods of use therefor
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, (2008/06/13)
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a substituted 1,2,4-triazine of the formula (I) STR1 and the biologically and pharmaceutically acceptable salts thereof; capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
SYNTHESIS, STRUCTURE, AND CYTOTOXICITY EVALUATION OF PALLADIUM(II) COMPLEXES OF 4-AMINO-3-HYDRAZINO-1,2,4-TRIAZIN-5(4H)-ONES AND 4-AMINO-3-(N-METHYLHYDRAZINO)-1,2,4-TRIAZIN-5(4H)-ONES
Borrell, J. I.,Victory, P.,Beti, C.,Batllori, X.,Schaeidt, H.,et al.
, p. 243 - 252 (2007/10/03)
The synthesis and structure of the Pd(II) complexes of the 3-hydrazino- and 4-amino-3-(N-methylhydrazino)-1,2,4-triazin-5(4H)-ones (5a-d and 6a-c) is reported.The ligands were obtained by following a general procedure previously descibed in the literature
Iminophosphorane-mediated Syntheses of Triazolotriazines. The Unexpected Formation of Z,Z-1,3-Diazetidine-2,4-di-imines. X-Ray Molecular Structure of 7-(p-Chloroanilino)-8-(p-chlorophenyl)-3-methyltriazolotriazin-4(8H)-one and of 1,3-Bis-(p-ch...
Molina, Pedro,Alajarin, Mateo,Saez, Jose Ramon,Foces-Foces, Ma de la Concepcion,Cano, Felix Hernandez,et al.
, p. 2037 - 2050 (2007/10/02)
A number of triazolotriazine derivatives have been prepared. 6-Methyl-3-methylthio-4-triphenylphosphoranylideneamino-5-oxo-4,5-dihydro-1,2,4-triazine (19) reacts with aryl isocyanates to yield the corresponding 1,3-diaryl-2,4-bis-(6-methyl-3-methylthio-5-oxo-4,5-dihydro-1,2,4-triazin-4-ylimino)-1,3-diazetidines (20)-(24); these undergo ring cleavage on treatment with aqueous ethanol to give the 8-aryl-7-arylamino-3-methyltriazolotriazin-4(8H)-ones (8), (12), and (16)-(18).The reaction of the 3-arylmethylenehydrazino-6-methyl-5-oxo-4-triphenylphosphoranylideneamino-4,5-dihydro-1,2,4-triazines (35) and (36), available from the corresponding 4-amino-3-arylmethylenehydrazino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazine and triphenylphosphine dibromide, with alkyl or aryl isocyanates led directly to 7-arylamino-8-arylmethyleneamino-3-methyltriazolotriazin-4(8H)-ones (37)-(46).Also, iminophosphoranes (5)-(7), (35), and (36) react with acyl chlorides in the presence of triethylamine to give the triazolotriazinones (25)-(31) and (50)-(55) respectively.Structures of compounds (20)-(24) have been established by means of (13)C n.m.r. analysis and X-ray crystallography.
