89131-11-3

Basic information

• Product Name: DABSYL-L-VALINE
• Synonyms: 4-DIMETHYLAMINOAZOBENZENE-4'-SULFONYL-L-VALINE;DABSYL-L-VALINE;Dbs-Val-OH;N-[[4-[[4-(Dimethylamino)phenyl]azo]phenyl]sulfonyl]-L-valine;4-Dimethylaminoazobenzene-4'-sulfonyl-L-valine Dbs-Val-OH;Dabsyl-L-valine
• CAS NO: 89131-11-3
• Molecular Formula: C₁₉H₂₄N₄O₄S
• Molecular Weight: 404.48
• Product Categories: Amino Acids;Amino Acids (N-Protected);Biochemistry;Dabsyl Amino Acids
• Mol File: 89131-11-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 615.438oC at 760 mmHg
• Flash Point: 326.005oC
• Appearance: /
• Density: 1.274g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: DABSYL-L-VALINE(CAS DataBase Reference)
• NIST Chemistry Reference: DABSYL-L-VALINE(89131-11-3)
• EPA Substance Registry System: DABSYL-L-VALINE(89131-11-3)

Safety Data

• Hazardous Substances Data: 89131-11-3(Hazardous Substances Data)

Usage

General Description

DABSYL-L-VALINE is a chemical compound consisting of the amino acid L-valine attached to the DABSYL (dimethylaminoazo) group. It is commonly used in analytical chemistry as a derivatization reagent for the quantification and detection of amino acids. The DABSYL group enables the compound to be detected using spectroscopic methods such as UV absorbance or fluorescence, allowing for the sensitive and precise measurement of L-valine levels in complex biological samples. DABSYL-L-VALINE is often utilized in studies related to protein synthesis, amino acid metabolism, and disease diagnostics.

InChI:InChI=1/C19H24N4O4S/c1-13(2)18(19(24)25)22-28(26,27)17-11-7-15(8-12-17)21-20-14-5-9-16(10-6-14)23(3)4/h5-13,18,22H,1-4H3,(H,24,25)/b21-20+/t18-/m0/s1

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Relevant articles and documents

Center-of-mass iso-energetic collision-induced decomposition in tandem triple quadrupole mass spectrometry

Two scan modes of the triple quadrupole tandem mass spectrometer, namely Collision Induced Dissociation Precursor Ion scan and Neutral Loss scan, allow selectively pinpointing, in a complex mixture, compounds that feature specific chemical groups, which yield characteristic fragment ions or are lost as distinctive neutral fragments. This feature of the triple quadrupole tandem mass spectrometer allows the non-target screening of mixtures for classes of components. The effective (center-of-mass) energy to achieve specific fragmentation depends on the inter-quadrupole voltage (laboratory-frame collision energy) and on the masses of the precursor molecular ion and of the collision gas, through a non-linear relationship. Thus, in a class of homologous compounds, precursor ions activated at the same laboratory-frame collision energy face different center-of-mass collision energy, and therefore the same fragmentation channel operates with different degrees of efficiency. This article reports a linear equation to calculate the laboratory-frame collision energy necessary to operate Collision-Induced Dissociation at the same center-of-mass energy on closely related compounds with different molecular mass. A routine triple quadrupole tandem mass spectrometer can operate this novel feature (iso-energetic collision-induced dissociation scan; i-CID) to analyze mixtures of endogenous metabolites by Precursor Ion and Neutral Loss scans. The latter experiment also entails the hitherto unprecedented synchronized scanning of all three quadrupoles of the triple quadrupole tandem mass spectrometer. To exemplify the application of this technique, this article shows two proof-of-principle approaches to the determination of biological mixtures, one by Precursor Ion analysis on alpha amino acid derivatized with a popular chromophore, and the other on modified nucleosides with a Neutral Fragment Loss scan.