89131-13-5Relevant articles and documents
Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria
Pruksakorn, Patamaporn,Arai, Masayoshi,Kotoku, Naoyuki,Vilchze, Catherine,Baughn, Anthony D.,Moodley, Prashini,Jacobs Jr., William R.,Kobayashi, Motomasa
, p. 3658 - 3663 (2010)
Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.