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891364-75-3

N-(4-fluorophenyl)-2-(1H-indole-3-carbonyl)hydrazinecarbothioamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 891364-75-3 Structure

  • Basic information

    1. Product Name: N-(4-fluorophenyl)-2-(1H-indole-3-carbonyl)hydrazinecarbothioamide
    2. Synonyms: N-(4-fluorophenyl)-2-(1H-indole-3-carbonyl)hydrazinecarbothioamide
    3. CAS NO:891364-75-3
    4. Molecular Formula:
    5. Molecular Weight: 328.37
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 891364-75-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(4-fluorophenyl)-2-(1H-indole-3-carbonyl)hydrazinecarbothioamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(4-fluorophenyl)-2-(1H-indole-3-carbonyl)hydrazinecarbothioamide(891364-75-3)
    11. EPA Substance Registry System: N-(4-fluorophenyl)-2-(1H-indole-3-carbonyl)hydrazinecarbothioamide(891364-75-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 891364-75-3(Hazardous Substances Data)

891364-75-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 891364-75-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,1,3,6 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 891364-75:
(8*8)+(7*9)+(6*1)+(5*3)+(4*6)+(3*4)+(2*7)+(1*5)=203
203 % 10 = 3
So 891364-75-3 is a valid CAS Registry Number.

891364-75-3Downstream Products

891364-75-3Relevant articles and documents

Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents

Hamdy, Rania,Ziedan, Noha I.,Ali, Samia,Bordoni, Cinzia,El-Sadek, Mohamed,Lashin, Elsaid,Brancale, Andrea,Jones, Arwyn T.,Westwell, Andrew D.

, p. 1037 - 1040 (2017)

A series of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines 8a–j has been designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2-inhibitory anticancer agents based on our previous lead compound 8a. Synthesis of the target compounds was readily accomplished through a cyclisation reaction between indole-3-carboxylic acid hydrazide (5) and substituted isothiocyanates 6a–j, followed by oxidative cyclodesulfurization of the corresponding thiosemicarbazide 7a–j using 1,3-dibromo-5,5-dimethylhydantoin. Active compounds of the series 8a–j were found to have sub-micromolar IC50 values selectively in Bcl-2 expressing human cancer cell lines; notably the 2-nitrophenyl analogue 8a was found to exhibit potent activity, and compounds 8a and 8e possessed comparable Bcl-2 binding affinity (ELISA assay) to the established natural product-based Bcl-2 inhibitor, gossypol. Molecular modeling studies helped to further rationalise anti-apoptotic Bcl-2 binding, and identified compounds 8a and 8e as candidates for further development as Bcl-2 inhibitory anticancer agents.

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