891491-99-9

Usage

Uses

Used in Organic Synthesis:
(6-(Dimethylamino)naphthalen-2-yl)methanol is used as a building block in organic synthesis for the creation of various biologically active molecules. Its unique structure allows for the development of new compounds with potential applications in various fields.
Used in Pharmaceutical Research:
In pharmaceutical research, (6-(Dimethylamino)naphthalen-2-yl)methanol is used as a key component in the synthesis of drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties of the final product.
Used in Fluorescent Dyes Production:
(6-(Dimethylamino)naphthalen-2-yl)methanol is used as a reagent in the production of fluorescent dyes. Its chemical properties make it suitable for creating dyes that can be used in various applications, such as bioimaging and diagnostics.
Used in Optical Brighteners Production:
(6-(DiMethylaMino)naphthalen-2-yl)Methanol is also used in the production of optical brighteners, which are additives used to make materials appear brighter and more vivid. Its role in the synthesis process contributes to the development of effective brightening agents.
Used in Material Development:
(6-(Dimethylamino)naphthalen-2-yl)methanol has potential applications in the development of new materials. Its unique chemical structure can be utilized to create innovative materials with specific properties for various industries.
Used as a Chemical Probe in Biological Studies:
In biological studies, (6-(Dimethylamino)naphthalen-2-yl)methanol can be used as a chemical probe to investigate biological processes and interactions. Its ability to bind with certain molecules can provide valuable insights into the mechanisms of various biological systems.

Upstream product

• 5043-06-1 methyl 6-(dimethylamino)-2-naphthoate 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 173471-71-1 6‐(dimethylamino)‐2-naphthaldehyde 
• 5043-03-8 6?bromo?N,N?dimethylnaphthalen?2?amine 
• 5043-05-0 6-(N,N-dimethylamino)-2-naphthoic acid 

Downstream Products

• 173471-71-1 6‐(dimethylamino)‐2-naphthaldehyde 

Relevant academic research and scientific papers

Histone deacetylase fluorescence probe, and preparation method and applications thereof

The invention provides a histone deacetylase fluorescence probe, and a preparation method and applications thereof. The structure formula of the histone deacetylase fluorescence probe is disclosed inthe invention. In synthesis, 6-(dimethylamino)-2-naphthaldehyde with two-photon effect is selected as a dye, so that further nucleophilic reaction is realized after deacetylation reaction, and fluorescence signals are generated; aldehyde group carbon is modified into cyanogroup alcohol structures, hydroxyl is connected with HDACs responsive groups, and the histone deacetylase fluorescence probe isused for detecting and imaging of the activity of histone deacetylase in tissue. According to the histone deacetylase fluorescence probe, cyanogroup with excellent electron-withdrawing capability isintroduced, so that after response of HDACs with the histone deacetylase fluorescence probe, intramolecular cyclization reaction is carried out rapidly, activation of fluorescence signals is realized,detecting and imaging on histone deacetylase in living cells and tissue are realized, and excellent clinical application value is achieved.

Discovery of a sensitive, selective, and tightly binding fluorogenic substrate of bovine plasma amine oxidase

(Chemical Equation Presented) We report a novel fluorogenic substrate of bovine plasma amine oxidase (BPAO), namely, (2-(6-(aminomethyl)naphthalen-2- yloxy)ethyl)trimethylammonium (ANETA), which displays extremely tight binding to BPAO (Km 183 ± 14 nM) and yet is metabolized fairly quickly (kcat 0.690 ± 0.010 s-1), with the aldehyde turnover product (2-(6-formylnaphthalen-2-yloxy)ethyl)trimefhylammonium serving as a real time reporting fluorophore of the enzyme activity. This allowed for the development of a fluorometric noncoupled assay that is 2 orders of magnitude more sensitive than the spectrophotometric benzylamine assay. The discovery of ANETA involved elaboration of the lead compound 6-methoxy-2-naphthalene- methaneamine by structure-based design, which recognized the ancillary cation binding site of BPAO as the most significant structural features controlling binding affinity. Structure-based design further ensured a high level of selectivity: ANETA is a good substrate of BPAO but is not a substrate of either porcine kidney diamine oxidase (pkDAO) or rat liver monoamine oxidase (MAO-B). ANETA represents the first highly sensitive, selective, and tight binding fluorogenic substrate of a copper amine oxidase that is able to respond directly to the enzyme activity in real time.

Prodan-containing nucleotide and use thereof

A compound represented by formula (1): wherein R1 is a substituent represented by formula (2): wherein R2 is ═O or —NH2, with the proviso that when R2 is ═O, H is attached to the 1-position N of the pyrimidine ring, and the bond between the 1-position N and the 6-position C is a single bond; or a substituent represented by formula (3): wherein R3 is —OH, ═O, or —NH2, with the proviso that when R3 is —OH or —NH2, R4 is H; when R3 is ═O, R4 is —NH2; and when R3 is ═O, H is attached to the 1-position N of the purine ring, and the bond between the 1-position N and the 6-position C is a single bond.