89159-60-4 Usage
Uses
Used in Pharmaceutical Industry:
CHEMBRDG-BB 5280909 is used as a selective protease activated receptor 4 (PAR-4) antagonist for its antithrombotic effects, potentially offering a targeted approach to treating conditions related to blood clotting and vascular health.
Biochem/physiol Actions
ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist.
IC 50
140 nm
references
[1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713.
Check Digit Verification of cas no
The CAS Registry Mumber 89159-60-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,1,5 and 9 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 89159-60:
(7*8)+(6*9)+(5*1)+(4*5)+(3*9)+(2*6)+(1*0)=174
174 % 10 = 4
So 89159-60-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H14N2O3/c1-17-14-8-7-12(18(20)21)9-13(14)16(15(17)10-19)11-5-3-2-4-6-11/h2-9,19H,10H2,1H3
89159-60-4Relevant academic research and scientific papers
A NEW APPROACH TO THE SYNTHESIS OF 2-AMINOMETHYL-3-PHENYL-5-NITROINDOLE
Krichevskii, E. S.,Romanova, O. B.,Grinev, A. N.
, p. 1302 - 1305 (2007/10/02)
Bromination of 2-methyl-3-phenyl-5-nitroindoles has given previously unknown 2-bromoethyl-3-phenyl-5-nitroindoles, which were converted by the Delepine reaction into 2-aminomethyl-3-phenyl-5-nitroindoles.One of these (1-methyl-2-aminomethyl-3-phenyl-5-nitroindole) was also obtained by reductive amination of 1-methyl-2-formyl-3-phenyl-5-nitroindole by the Leuckart-Wallach reaction.
