891772-28-4

Upstream product

• 891772-15-9 3-(6-methoxy-pyridin-2-yl)-prop-2-ynoic acid methyl ester 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 

Downstream Products

• 891772-56-8 3-benzyl-5-(6-methoxy-pyridin-2-yl)-3-aza-bicyclo[3.1.0]hexane-1-carboxylic acid methyl ester 
• 891772-35-3 1-benzyl-4-(6-methoxy-pyridin-2-yl)-pyrrolidine-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Deconstructing cytisine: The syntheses of (±)-cyfusine and (±)-cyclopropylcyfusine, fused ring analogs of cytisine

A novel fused tricyclic analog (11) of cytisine has been prepared (coined 'cyfusine') and determined to have high affinity at neuronal nicotinic acetylcholine receptors. A [3 + 2] cycloaddition protocol permitted entry into a 3,4-differentially difunction

1, 2, 3, 3A, 8, 8A-HEXAHYDRO-2, 7A-DIADA-CYCLOPENTA [A] INDEN-7-ONE DERIVATIVES WHICH BIND TO NEURONAL NICOTINIC ACETYLCHOLINE SPECIFIC RECEPTOR SITES AND ARE USEFUL IN MODULATING CHOLINERGIC FUNCTION AND IN THE TREATMENT OF ADDICTIVE DISORDERS

The present invention relates to novel fused bicyclicpyrrolidine pyridone compounds of the formula (I) wherein R, RP and n are as defined herein, their pharmaceutically acceptable salts, pharmaceutical compositions and their use in treating addictive disorders such as the use of tobacco or other nicotine containing products and in the treatment of neurological and mental disorders related to a decrease in cholinergic function.