891778-35-1Relevant academic research and scientific papers
Diastereoselective arylation of l-proline derivatives at the 5-position
Onomura, Osamu,Kirira, Peter G.,Tanaka, Toshimitsu,Tsukada, Shinsuke,Matsumura, Yoshihiro,Demizu, Yosuke
, p. 7498 - 7503 (2008/12/20)
Diastereoselective introduction of nucleophiles into l-proline derivatives at the 5-position was achieved with suitable selection of N-protecting group. N-Methoxycarbonylated or benzyloxycarbonylated l-proline derivatives reacted with arene to give cis-ar
New efficient organic activators for highly enantioselective reduction of aromatic ketones by trichlorosilane
Matsumura, Yoshihiro,Ogura, Kanako,Kouchi, Yoshimi,Iwasaki, Fumiaki,Onomura, Osamu
, p. 3789 - 3792 (2007/10/03)
Aryl ketones were reduced to the corresponding alcohols with excellent enantioselectivity (up to 99.7% ee) by Cl3SiH in the presence of a catalytic amount of N-formyl-α′-(2,4,6-triethylphenyl)-L-proline as an activator. Both carboxyl group at the α-position of the activator and 2,4,6-triethylphenyl group at the α′-position were critical for the high enantioselectivity.
