891778-45-3

Upstream product

• 3154-58-3 N-Formyl-L-proline methyl ester 
• 891778-31-7 methyl N-formyl-α'-methoxy-L-prolinate 
• 91736-26-4 methyl trans-N-formyl-α'-(2,4,6-trimethylphenyl)-L-prolinate 

Relevant academic research and scientific papers

New efficient organic activators for highly enantioselective reduction of aromatic ketones by trichlorosilane

Aryl ketones were reduced to the corresponding alcohols with excellent enantioselectivity (up to 99.7% ee) by Cl3SiH in the presence of a catalytic amount of N-formyl-α′-(2,4,6-triethylphenyl)-L-proline as an activator. Both carboxyl group at the α-position of the activator and 2,4,6-triethylphenyl group at the α′-position were critical for the high enantioselectivity.