891782-65-3Relevant academic research and scientific papers
PROCESSES FOR THE PREPARATION OF 4-{4-[5(S)-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL]PHENYL} MORPHOLIN-3-ONE
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Page/Page column 18, (2013/03/26)
The present invention provides simple, eco-friendly, cost-effective, reproducible, robust and industrial processes for the preparation of intermediate compound 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (II). The present invention also provides novel intermediates and their use in the synthesis of morpholinone oxazolidine derivatives.
A facile synthesis of 2-((5R)-2-oxo-5-oxazolidinyl)methyl-1H-isoindole-1, 3(2H)-dione
Madhusudhan,Ready, G. Om,Ramanatham,Dubey
, p. 1264 - 1268 (2007/10/03)
Synthesis of enantiomerically pure 2-((5A)-2-oxo-5-oxazolidinyl) methyl)-1H-isoindole-1,3(2H)-dione, a key precursor in the preparation of oxazolidinone class of antibacterial agents starting from (S)-epichlorohydrin has been achieved.
A novel and short convergent approach for N-aryl-5-aminomethyl-2- oxazolidinone derivatives Linezolid and DUP-721
Madhusudhan,Om Reddy,Ramanatham,Dubey
, p. 1236 - 1238 (2007/10/03)
A new convergent and short approach for oxazolidinone class of antibacterial agents, Linezolid and DUP-721, has been achieved by condensing 3-chloro-2-((phenoxycarbonyl)oxy) propyl azide with aryl amine followed by reductive acetylation. This one pot approach for N-aryl-5-azidomethyl- 2-oxazolidinone could provide access for rapid preparation of various oxazolidinone analogues.
