89179-59-9Relevant academic research and scientific papers
Heteroaromatic Primary Amines and Formaldehyde: the Formation of N-Hydroxymethyl Derivatives
Verardo, Giancarlo,Gorassini, Fausto,Giumanini, Angelo G.,Scubla, Tiziano,Tolazzi, Marilena,Strazzolini, Paolo
, p. 8311 - 8322 (1995)
A product study of the reaction of three heteroaromatic primary amines with paraformaldehyde was made: N-hydroxymethylamines were identified in all cases.Two of them yielded also N,N-dihydroxymethyl derivatives.X-Ray diffraction structure determination on one of the N-hydroxymethyl derivatives ruled out the presence of internal hydrogen bonding in the solid state, notwithstanding the almost ideally planar arrangement of the aromatic moiety and the amino function.
